Ovine ureteral motility as a new assay for the cyclo-oxygenase blocking potency of non steroidal anti-inflammatory drugs.
Gen Pharmacol
; 18(3): 337-40, 1987.
Article
en En
| MEDLINE
| ID: mdl-3106138
Isolated sheep ureteral ring suspended in an organ bath exhibits rhythmic contractions which are dose-dependently inhibited by indomethacin and revived by prostaglandin E2 or F2 alpha. Seven non-steroidal anti-inflammatory drugs (NSAID) belonging to different chemical groups were tested on the isolated ureteral ring model in molar concentrations of 10(-8)-10(-4) to determine the time elapsing from application of test drug to complete inhibition of ureteral contraction ("stop-time"). The descending order of potency of the NSAID was: flurbiprofen greater than indomethacin greater than flufenamic acid greater than tolmetin greater than aspirin greater than phenylbutazone greater than isoxicam. A parallelism was observed in the plot of log concentration of NSAID and "stop-time" amongst all compounds except aspirin and isoxicam. The sheep isolated ring preparation is a simple reproducible biological model for assessment of anti-inflammatory cyclo-oxygenase inhibitory activity of compounds.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Contracción Uterina
/
Antiinflamatorios no Esteroideos
/
Inhibidores de la Ciclooxigenasa
Límite:
Animals
Idioma:
En
Revista:
Gen Pharmacol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Reino Unido