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Citrobacter rodentium Induces Tissue-Resident Memory CD4+ T Cells.
Bishu, S; Hou, G; El Zaatari, M; Bishu, S R; Popke, D; Zhang, M; Grasberger, H; Zou, W; Stidham, R W; Higgins, P D R; Spence, J R; Kamada, N; Kao, J Y.
Afiliación
  • Bishu S; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA bishus@med.umich.edu.
  • Hou G; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • El Zaatari M; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Bishu SR; University of Michigan Crohn's and Colitis Program, Ann Arbor, Michigan, USA.
  • Popke D; Consolidated Pathology Consultants, Northwestern Lake Forest Hospital, Lake Forest, Illinois, USA.
  • Zhang M; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Grasberger H; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Zou W; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Stidham RW; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • Higgins PDR; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Spence JR; University of Michigan Crohn's and Colitis Program, Ann Arbor, Michigan, USA.
  • Kamada N; Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Kao JY; University of Michigan Crohn's and Colitis Program, Ann Arbor, Michigan, USA.
Infect Immun ; 87(7)2019 07.
Article en En | MEDLINE | ID: mdl-31061145
Tissue-resident memory T cells (TRM cells) are a novel population of tissue-restricted antigen-specific T cells. TRM cells are induced by pathogens and promote host defense against secondary infections. Although TRM cells cannot be detected in circulation, they are the major memory CD4+ and CD8+ T-cell population in tissues in mice and humans. Murine models of CD8+ TRM cells have shown that CD8+ TRM cells maintain tissue residency via CD69 and though tumor growth factor ß-dependent induction of CD103. In contrast to CD8+ TRM cells, there are few models of CD4+ TRM cells. Thus, much less is known about the factors regulating the induction, maintenance, and host defense functions of CD4+ TRM cells. Citrobacter rodentium is known to induce IL-17+ and IL-22+ CD4+ T cells (Th17 and Th22 cells, respectively). Moreover, data from IL-22 reporter mice show that most IL-22+ cells in the colon 3 months after C. rodentium infection are CD4+ T cells. This collectively suggests that C. rodentium may induce CD4+ TRM cells. Here, we demonstrate that C. rodentium induces a population of IL-17A+ CD4+ T cells that are tissue restricted and antigen specific, thus meeting the criteria of CD4+ TRM cells. These cells expand and are a major source of IL-22 during secondary C. rodentium infection, even before the T-cell phase of the host response in primary infection. Finally, using FTY 720, which depletes circulating naive and effector T cells but not tissue-restricted T cells, we show that these CD4+ TRM cells can promote host defense.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Citrobacter rodentium / Infecciones por Enterobacteriaceae Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Infect Immun Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Citrobacter rodentium / Infecciones por Enterobacteriaceae Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Infect Immun Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos