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Abnormal expression of the co-stimulatory molecule B7-H3 in lichen simplex chronicus is associated with expansion of Langerhans cells.
Feng, X; Yang, M; Yang, Z; Qian, Q; Burns, E M; Min, W.
Afiliación
  • Feng X; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
  • Yang M; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
  • Yang Z; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
  • Qian Q; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
  • Burns EM; Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Min W; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Clin Exp Dermatol ; 45(1): 30-35, 2020 Jan.
Article en En | MEDLINE | ID: mdl-31056761
BACKGROUND: The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC). AIM: To investigate if abnormal expression of the co-stimulatory molecule B7-H3 in LSC is associated with Langerhans cell (LC) expansion. METHODS: We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7-H3 and interleukin (IL)-6 was significantly different. RESULTS: Our results indicated that B7-H3 is abnormally expressed in LSC skin tissue and positively regulates LC expansion. We also found that IL-6 might modulate B7-H3 expression. Moreover, LC expansion in LSC leads to the proliferation of T cells. CONCLUSIONS: Our study indicates the potential value of immunotherapy as a treatment for LSC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Células de Langerhans / Interleucina-6 / Antígenos B7 / Neurodermatitis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Dermatol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Células de Langerhans / Interleucina-6 / Antígenos B7 / Neurodermatitis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Dermatol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido