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Anti-melanin deposition activity and active constituents of Jatropha multifida stems.
Woo, So-Yeun; Wong, Chin Piow; Win, Nwet Nwet; Lae, Khine Zar Wynn; Woo, Bokyoung; Elsabbagh, Sherif Adel; Liu, Qian Qian; Ngwe, Hla; Morita, Hiroyuki.
Afiliación
  • Woo SY; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
  • Wong CP; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
  • Win NN; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
  • Lae KZW; Department of Chemistry, University of Yangon, Yangon, 11041, Myanmar.
  • Woo B; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
  • Elsabbagh SA; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
  • Liu QQ; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
  • Ngwe H; Department of Chemistry, University of Yangon, Yangon, 11041, Myanmar.
  • Morita H; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan. hmorita@inm.u-toyama.ac.jp.
J Nat Med ; 73(4): 805-813, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31055728
Jatropha multifida is a medicinal plant that belongs to the Euphorbiaceae family. Our investigation revealed that the chloroform extract of J. multifida stems showed anti-melanin deposition activity against α-melanocyte stimulating hormone (α-MSH)- and 3-isobutyl-1-methylxanthine (IBMX)-induced melanogenesis in the mouse melanoma cell line (B16-F10). Further fractionation and purification of the major constituents led to the isolation of two coumarins (1 and 2) and seven known lignoids (3-9). All isolated compounds exhibited anti-melanin deposition activities against the mouse melanoma cell line (B16-F10) with IC50 values ranging from 37.5 to 560.1 µM, without any cytotoxicity even at high concentrations, except for 8. Further mechanistic studies suggested that 9 downregulated tyrosinase mRNA expression, while the anti-melanin deposition activities of 4 and 8 appeared to be unrelated to tyrosinase inhibition and the downregulated expression of the key melanogenesis-associated mRNAs. These results suggested that J. multifida could possess potent skin whitening ingredients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Melanoma Experimental / Alfa-MSH / Extractos Vegetales / Jatropha / Melaninas Límite: Animals Idioma: En Revista: J Nat Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Melanoma Experimental / Alfa-MSH / Extractos Vegetales / Jatropha / Melaninas Límite: Animals Idioma: En Revista: J Nat Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón