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The impact of viral bronchiolitis phenotyping: Is it time to consider phenotype-specific responses to individualize pharmacological management?
Rodríguez-Martínez, Carlos E; Castro-Rodriguez, Jose A; Nino, Gustavo; Midulla, Fabio.
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  • Rodríguez-Martínez CE; Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia; Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine, Universidad El Bosque, Bogota, Colombia. Electronic address: carerodriguezmar@unal.edu.co.
  • Castro-Rodriguez JA; Department of Pediatric Pulmonology, Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
  • Nino G; Division of Pediatric Pulmonary, Sleep Medicine and Integrative Systems Biology, Center for Genetic Research, Children's National Medical Center, George Washington University, Washington, D.C., United States.
  • Midulla F; Department of Pediatrics, Sapienza University, Rome, Italy.
Paediatr Respir Rev ; 34: 53-58, 2020 Apr.
Article en En | MEDLINE | ID: mdl-31054799
Although recent guidelines recommend a minimalist approach to bronchiolitis, there are several issues with this posture. First, there are concerns about the definition of the disease, the quality of the guidelines, the method of administration of bronchodilators, and the availability of tools to evaluate the response to therapies. Second, for decades it has been assumed that all cases of viral bronchiolitis are the same, but recent evidence has shown that this is not the case. Distinct bronchiolitis phenotypes have been described, with heterogeneity in clinical presentation, molecular immune signatures and clinically relevant outcomes such as respiratory failure and recurrent wheezing. New research is critically needed to refine viral bronchiolitis phenotyping at the molecular and clinical levels as well as to define phenotype-specific responses to different therapeutic options.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Broncodilatadores / Bronquiolitis Viral / Ruidos Respiratorios Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Paediatr Respir Rev Asunto de la revista: PEDIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Broncodilatadores / Bronquiolitis Viral / Ruidos Respiratorios Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Paediatr Respir Rev Asunto de la revista: PEDIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido