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Interleukin-17 expression in the serum and exfoliated cervical cells of patients infected with high-risk oncogenic human papillomavirus.
Mareti Bonin, Camila; Zatorre Almeida-Lugo, Larissa; Rodrigues Dos Santos, Andrielli; Tezelli Junqueira Padovani, Cacilda; Silva Pina, Ana Flávia; Teixeira Ferreira, Alda Maria; Dos Santos Fernandes, Carlos Eurico; Possati Resende, Júlio César; Bovo, Adriane Cristina; Tozetti, Inês Aparecida.
Afiliación
  • Mareti Bonin C; Postgraduate Program of Infectious and Parasitary Diseases from Medicine School, Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil; Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil. Electronic address: camila.bonin@ufms.br.
  • Zatorre Almeida-Lugo L; Postgraduate Program of Infectious and Parasitary Diseases from Medicine School, Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
  • Rodrigues Dos Santos A; Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
  • Tezelli Junqueira Padovani C; Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
  • Silva Pina AF; Medicine School, Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
  • Teixeira Ferreira AM; Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
  • Dos Santos Fernandes CE; Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
  • Possati Resende JC; Cancer Hospital of Barretos (CHB), Campo Grande, Mato Grosso do Sul, Brazil.
  • Bovo AC; Cancer Hospital of Barretos (CHB), Campo Grande, Mato Grosso do Sul, Brazil.
  • Tozetti IA; Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
Cytokine ; 120: 92-98, 2019 08.
Article en En | MEDLINE | ID: mdl-31054481
Persistent infection by high-risk oncogenic human papillomavirus (HR-HPV) is the main cause of cervical cancer and its precursor lesions, and both the systemic and local immunological responses play an important role in eliminating or maintenance this infection. Th17 cells, as well as interleukin (IL)-17, are related to tumor growth and persistence of viral infection. Thus, this study aimed to quantify IL-17 in the serum and exfoliated cervical cells of HR-HPV-infected patients and healthy patients as well as identify CD4+IL17+ cells and IL-17 production in uterine cervix biopsies to better understand the behavior of this cytokine in HPV infections. IL-17 was quantified (pg/mL) in the serum and exfoliated cervical cells of 26 HR-HPV-infected patients, and in 18 healthy patients, using flow cytometry. Fifteen paraffin-embedded biopsy samples from the uterine cervix were subjected to immunohistochemistry to detect CD4+IL-17+ and IL-17+ cells. There was a significant increase in the concentration of IL-17 in HR-HPV-positive patients' serum when compared to that in samples of exfoliated cervical cells (p < 0.05). Likewise, when compared with that in healthy patients, the IL-17 concentration was still higher in HR-HPV-positive patients sera (p < 0.05). We did not find differences in the amount of CD4+IL-17+ cells and other IL-17-secreting cells between different histopathological lesions. Our results suggest that HR-HPV infection predominantly stimulates systemic IL-17 production along with less localized expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oncogenes / Papillomaviridae / Cuello del Útero / Interleucina-17 / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oncogenes / Papillomaviridae / Cuello del Útero / Interleucina-17 / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido