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Role of RNA secondary structures in regulating Dscam alternative splicing.
Xu, Bingbing; Shi, Yang; Wu, Yandan; Meng, Yijun; Jin, Yongfeng.
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  • Xu B; MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang ZJ310058, PR China.
  • Shi Y; MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang ZJ310058, PR China.
  • Wu Y; MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang ZJ310058, PR China.
  • Meng Y; College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang ZJ310018, PR China.
  • Jin Y; MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang ZJ310058, PR China. Electronic address: jinyf@zju.edu.cn.
Biochim Biophys Acta Gene Regul Mech ; 1862(11-12): 194381, 2019.
Article en En | MEDLINE | ID: mdl-31048027
Alternative splicing of mRNA precursors is a versatile mechanism of expanding proteomic diversity. The most striking example of this is the Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) gene, which potentially encodes 38,016 distinct isoforms by mutually exclusive splicing. The genomic organization of Dscam1 is largely conserved across the pancrustaceans, although the number of splice isoforms varies from 2240 in the clam shrimp (Eulimnadia texana) to 121,104 in the whiteleg shrimp (Litopenaeus vannamei). RNA secondary structure plays a pivotal role in mutually exclusive splicing of Dscam1. Here, we review recent progress in the identification, evolution, and regulatory roles of RNA secondary structure in alternative splicing of Dscam1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Moléculas de Adhesión Celular / Proteínas de Drosophila / Drosophila melanogaster Límite: Animals Idioma: En Revista: Biochim Biophys Acta Gene Regul Mech Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Moléculas de Adhesión Celular / Proteínas de Drosophila / Drosophila melanogaster Límite: Animals Idioma: En Revista: Biochim Biophys Acta Gene Regul Mech Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos