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Poly(photosensitizer) Nanoparticles for Enhanced in Vivo Photodynamic Therapy by Interrupting the π-π Stacking and Extending Circulation Time.
Zheng, Nan; Zhang, Zhiyi; Kuang, Jia; Wang, Chunsen; Zheng, Yubin; Lu, Qing; Bai, Yugang; Li, Yang; Wang, Aiguo; Song, Wangze.
Afiliación
  • Zheng N; State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Linggong Rd. 2 , Dalian , Liaoning 116023 , China.
  • Zhang Z; State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Linggong Rd. 2 , Dalian , Liaoning 116023 , China.
  • Kuang J; State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Linggong Rd. 2 , Dalian , Liaoning 116023 , China.
  • Wang C; Department of Comparative Medicine Laboratory Animal Center , Dalian Medical University , No. 9 Lvshun South Road , Dalian , Liaoning 116000 , China.
  • Zheng Y; State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Linggong Rd. 2 , Dalian , Liaoning 116023 , China.
  • Lu Q; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chem/Bio-sensing and Chemometrics, Department of Chemistry , Hunan University Changsha , Hunan 410000 , China.
  • Bai Y; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chem/Bio-sensing and Chemometrics, Department of Chemistry , Hunan University Changsha , Hunan 410000 , China.
  • Li Y; State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Linggong Rd. 2 , Dalian , Liaoning 116023 , China.
  • Wang A; Department of Comparative Medicine Laboratory Animal Center , Dalian Medical University , No. 9 Lvshun South Road , Dalian , Liaoning 116000 , China.
  • Song W; State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Linggong Rd. 2 , Dalian , Liaoning 116023 , China.
ACS Appl Mater Interfaces ; 11(20): 18224-18232, 2019 May 22.
Article en En | MEDLINE | ID: mdl-31046231
The natural planar and rigid structures of most of the hydrophobic photosensitizers (PSs) [such as tetraphenyl porphyrin (TPP)] significantly reduce their loading efficiencies in polymeric nanoparticles (NPs) because of the strong π-π interaction-induced aggregation. This aggregation-caused quenching will further reduce the quantum yield of singlet oxygen (1O2) generation and weaken the efficiency of photodynamic therapy (PDT). In addition, the small molecular PSs exhibit short tumor retention time and tend to be easily cleared once released. Herein, poly(TPP) NPs, prepared by cross-linking of reactive oxygen species degradable, thioketal linkers and TPP derivatives, followed by coprecipitation, were first developed with quantitative loading efficiency (>99%), uniform NP sizes (without aggregation), increased singlet oxygen quantum yield (ΦΔ = 0.79 in dimethyl sulfoxide compared with 0.52 for original TPP), increased in vitro phototoxicity, extended tumor retention time, light-triggered on-demand release, and enhanced in vivo antitumor efficacy, which comprehensively address the multiple issues for most of the PSs in the PDT area.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Porfirinas / Fármacos Fotosensibilizantes / Nanopartículas / Neoplasias Experimentales Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Porfirinas / Fármacos Fotosensibilizantes / Nanopartículas / Neoplasias Experimentales Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos