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Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective.
Mutombo, Polydor Ngoy; Man, Nicola W Y; Nejsum, Peter; Ricketson, Robert; Gordon, Catherine A; Robertson, Gemma; Clements, Archie C A; Chacón-Fonseca, Nathalie; Nissapatorn, Veeranoot; Webster, Joanne P; McLaws, Mary-Louise.
Afiliación
  • Mutombo PN; School of Public Health and Community Medicine, UNSW Medicine, UNSW, Sydney, NSW, Australia; Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia. Electronic address: polydorngoymutombo@gmail.com.
  • Man NWY; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
  • Nejsum P; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
  • Ricketson R; Hale O'mana'o Biomedical Research, Division of Emerging Pathogens, Edmond, OK, United States.
  • Gordon CA; Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Robertson G; Public and Environmental Health, Forensic and Scientific Services, Department of Health, Brisbane, QLD, Australia.
  • Clements ACA; Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
  • Chacón-Fonseca N; Soil-Transmitted Helminths Section, Tropical Medicine Institute, Tropical Medicine Department, Faculty of Medicine, Central University of Venezuela, Caracas, Venezuela.
  • Nissapatorn V; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand; Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand.
  • Webster JP; Centre for Emerging, Endemic and Exotic Diseases (CEEED), Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, United Kingdom.
  • McLaws ML; School of Public Health and Community Medicine, UNSW Medicine, UNSW, Sydney, NSW, Australia. Electronic address: m.mclaws@unsw.edu.au.
Adv Parasitol ; 104: 247-326, 2019.
Article en En | MEDLINE | ID: mdl-31030770
Soil-transmitted helminth (STH) infections represent a major public health problem globally, particularly among socio-economically disadvantaged populations. Detection of STH infections is often challenging, requiring a combination of diagnostic techniques to achieve acceptable sensitivity and specificity, particularly in low infection-intensity situations. The microscopy-based Kato-Katz remains the most widely used method but has low sensitivity in the detection of, for instance, Strongyloides spp. infections, among others. Antigen/antibody assays can be more sensitive but are parasite species-specific. Highly sensitive PCR methods have been developed to be multiplexed to allow multi-species detection. Novel diagnostic tests for all STH species are needed for effective monitoring, evaluation of chemotherapy programmes, and to assess the potential emergence of parasite resistance. This review discusses available diagnostic methods for the different stages of STH control programmes, which vary in sensitivity and spectrum of detection requirements, and tools to evaluate drug efficacy and resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Medicamentos / Salud Pública / Helmintiasis Tipo de estudio: Diagnostic_studies Aspecto: Determinantes_sociais_saude Límite: Animals / Humans Idioma: En Revista: Adv Parasitol Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Medicamentos / Salud Pública / Helmintiasis Tipo de estudio: Diagnostic_studies Aspecto: Determinantes_sociais_saude Límite: Animals / Humans Idioma: En Revista: Adv Parasitol Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido