Your browser doesn't support javascript.
loading
Recurrent early stage endometrial cancer: Patterns of recurrence and results of salvage therapy.
Francis, Samual R; Ager, Bryan J; Do, Olivia A; Huang, Yu-Huei Jessica; Soisson, Andrew P; Dodson, Mark K; Werner, Theresa L; Sause, William T; Grant, Jonathan D; Gaffney, David K.
Afiliación
  • Francis SR; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Ager BJ; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Do OA; Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Huang YJ; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Soisson AP; Department of Obstetrics and Gynecology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Dodson MK; Department of Obstetrics and Gynecology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Werner TL; Department of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Sause WT; Department of Radiation Oncology, Intermountain Medical Group, Intermountain Healthcare, Salt Lake City, UT, USA.
  • Grant JD; Department of Radiation Oncology, Intermountain Medical Group, Intermountain Healthcare, Salt Lake City, UT, USA.
  • Gaffney DK; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: david.gaffney@hci.utah.edu.
Gynecol Oncol ; 154(1): 38-44, 2019 07.
Article en En | MEDLINE | ID: mdl-31029507
OBJECTIVE: To analyze our institutional experience and oncologic outcomes for salvage treatment for the recurrence of early-stage endometrial cancer patients. METHODS: We included women of all ages diagnosed with FIGO stage I-II, any grade endometrial cancer from 2000 to 2016 at our institutions who were treated with at least a hysterectomy. Recurrences in the pelvis and/or vagina were considered locoregional recurrences (LRR). Overall survival (OS) was assessed using Kaplan-Meier survival analysis. Univariate (UV) and multivariate (MV) Cox proportional hazards modeling was also used. RESULTS: A total of 2691 women were analyzed. The majority had endometrioid histology (91%), stage IA disease (61%), and were grade 1 (57%). With a median follow-up of 6.1 years, the overall rate of recurrence was 7.2%, and the rate of LRR was 3.7%. Women with vaginal-only recurrences had a longer median OS after recurrence (14.0 years) compared to both pelvic (1.2 years) and distant (1.0 year) failures. For women with vaginal-only recurrences, salvage radiotherapy (RT) was the only factor associated with improved OS on MVA (HR 0.1, p = .04). For women with pelvic recurrences, salvage surgery (HR 0.3, p = .01), salvage RT (HR 0.3, p < .01), and salvage chemotherapy (HR 0.4, p = .03) were associated with improved OS. CONCLUSIONS: Failure rates for women with early-stage endometrial cancer are low. Women with vaginal-only recurrences have improved OS compared to pelvic or distant recurrences. Salvage RT appears to be an important factor for treatment of women with vaginal-only recurrences. Aggressive multimodality treatment may be beneficial for women with pelvic recurrences.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Recuperativa / Neoplasias Endometriales / Recurrencia Local de Neoplasia Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Gynecol Oncol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Recuperativa / Neoplasias Endometriales / Recurrencia Local de Neoplasia Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Gynecol Oncol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos