Your browser doesn't support javascript.
loading
Insights into the current status of privileged N-heterocycles as antileishmanial agents.
Razzaghi-Asl, Nima; Sepehri, Saghi; Ebadi, Ahmad; Karami, Pari; Nejatkhah, Negin; Johari-Ahar, Mohammad.
Afiliación
  • Razzaghi-Asl N; Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, PO Box 5618953141, Ardabil, Iran. n.razzaghi@pharmacy.arums.ac.ir.
  • Sepehri S; Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, PO Box 5618953141, Ardabil, Iran.
  • Ebadi A; Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Karami P; Biosensors and Bioelectronics Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
  • Nejatkhah N; Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, PO Box 5618953141, Ardabil, Iran.
  • Johari-Ahar M; Students Research Committee, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
Mol Divers ; 24(2): 525-569, 2020 May.
Article en En | MEDLINE | ID: mdl-31028558
Leishmania, one of the most important neglected tropical diseases, is endemic in several regions of the world and hence regarded as a serious threat to public health. Major difficulties with current chemotherapeutic agents raise issues such as toxicity, resistance, cost and other side effects. These issues necessitate development of potentially new chemical entities against diverse leishmanial species. Numerous natural and synthetic new antileishmanial molecules have been described for disease management. Careful inspection of scientific reports revealed that considerable amount of promising antileishmanial agents belonged to the nitrogen-containing heterocycles such as quinoline, triazole, pyrazole, imidazole, indole, pyrimidine, ß-carboline, quinoxaline, quinazoline and benzimidazole. In this regard, enormous chemical data provide the opportunity for systematic elucidation of structural requirements against different leishmanial species. Within this representation, insights into the current status of privileged N-heterocycles as antileishmanial agents with particular emphasis on structure activity relationships are reviewed.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis / Compuestos Heterocíclicos / Antiprotozoarios Límite: Animals / Humans Idioma: En Revista: Mol Divers Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis / Compuestos Heterocíclicos / Antiprotozoarios Límite: Animals / Humans Idioma: En Revista: Mol Divers Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos