Rioprostil prevents gastric bleeding induced by nonsteroidal antiinflammatory drugs in dogs and arthritic rats.
J Rheumatol
; 13(5): 887-94, 1986 Oct.
Article
en En
| MEDLINE
| ID: mdl-3102726
Gastrointestinal irritation is the most significant side effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAID) for treatment of arthritic conditions. Rioprostil, a primary alcohol prostaglandin E1 analog, prevents gastric bleeding induced by several NSAID in a rat model of arthritis that is similar in many aspects to human rheumatoid arthritis. Daily oral dosing of rioprostil (50 micrograms/kg BID for 15 days) did not influence the course of the adjuvant disease in rats or alter the antiinflammatory or analgesic effect of the NSAID. In a 13 week efficacy study in dogs, rioprostil (40-60 micrograms/kg, PO) completely prevented gastric hemorrhagic lesions induced by daily administration of aspirin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Artritis
/
Artritis Experimental
/
Prostaglandinas E
/
Úlcera Gástrica
/
Úlcera Péptica Hemorrágica
/
Antiinflamatorios no Esteroideos
/
Antiulcerosos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Rheumatol
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Canadá