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Cord blood fatty acid-binding protein-4 levels are upregulated at both ends of the birthweight spectrum.
Papathanasiou, Aimilia Eirini; Briana, Despina D; Gavrili, Stavroula; Georgantzi, Sophia; Papathoma, Evangelia; Marmarinos, Antonios; Christou, Christos; Voulgaris, Konstantinos; Gourgiotis, Dimitrios; Malamitsi-Puchner, Ariadne.
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  • Papathanasiou AE; Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Briana DD; Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Gavrili S; Neonatal Intensive Care Unit, 'Alexandra' University and State Maternity Hospital, Athens, Greece.
  • Georgantzi S; Neonatal Intensive Care Unit, 'Alexandra' University and State Maternity Hospital, Athens, Greece.
  • Papathoma E; Neonatal Intensive Care Unit, 'Alexandra' University and State Maternity Hospital, Athens, Greece.
  • Marmarinos A; Laboratory of Clinical Biochemistry-Molecular Diagnostics, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece.
  • Christou C; Hellenic Statistical Authority, Athens, Greece.
  • Voulgaris K; Hellenic Statistical Authority, Athens, Greece.
  • Gourgiotis D; Laboratory of Clinical Biochemistry-Molecular Diagnostics, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece.
  • Malamitsi-Puchner A; Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Acta Paediatr ; 108(11): 2083-2088, 2019 11.
Article en En | MEDLINE | ID: mdl-31025416
AIM: Fatty acid-binding protein-4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. We aimed to investigate at birth in term neonates with normal and abnormal intrauterine growth concentrations of FABP4 and associate them with various perinatal parameters. METHODS: Serum cord blood FABP4 levels were prospectively determined by ELISA in 80 singleton term appropriate-for-gestational-age (AGA), intrauterine growth-restricted (IUGR) and large-for-gestational-age (LGA) neonates. RESULTS: Compared to the AGA group, cord blood FABP4 levels were increased in the IUGR and LGA groups. Additionally, they were higher in early-term than full-term neonates. A significant U-shaped correlation was recorded between serum FABP4 levels and birthweight. A significant negative correlation between cord blood FABP4 and gestational age in the whole study population was noted. CONCLUSION: Cord blood FABP4 levels were significantly higher at the extremes of foetal growth at term and negatively correlated with gestational age, being increased in early-term versus full-term neonates. Further longitudinal studies with larger sample sizes are required to elucidate FABP4 implication in foetal growth and its association with future adverse cardiometabolic outcomes in the offspring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / Proteínas de Unión a Ácidos Grasos / Sangre Fetal Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: Acta Paediatr Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Noruega
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / Proteínas de Unión a Ácidos Grasos / Sangre Fetal Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: Acta Paediatr Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Noruega