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Is diffuse axonal injury on susceptibility weighted imaging a biomarker for executive functioning in adolescents with traumatic brain injury?
Vander Linden, Catharine; Verhelst, Helena; Genbrugge, Eva; Deschepper, Ellen; Caeyenberghs, Karen; Vingerhoets, Guy; Deblaere, Karel.
Afiliación
  • Vander Linden C; Ghent University Hospital, Child Rehabilitation Center K7, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Electronic address: catharine.vanderlinden@uzgent.be.
  • Verhelst H; Ghent University, Department of Experimental Psychology, Faculty of Psychology and Educational Sciences, Henri Dunantlaan 2, 9000, Ghent, Belgium. Electronic address: helena.verhelst@ugent.be.
  • Genbrugge E; Ghent University Hospital, Department of Neuroradiology, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Electronic address: eva.genbrugge@uzgent.be.
  • Deschepper E; Ghent University, Biostatistics Unit, Department of Public Health, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Electronic address: ellen.deschepper@ugent.be.
  • Caeyenberghs K; Australian Catholic University, Mary McKillop Institute for Health Research, Level 5, 215 Spring Street, Melbourne, VIC, 3000, Australia. Electronic address: karen.caeyenberghs@acu.edu.au.
  • Vingerhoets G; Ghent University, Department of Experimental Psychology, Faculty of Psychology and Educational Sciences, Henri Dunantlaan 2, 9000, Ghent, Belgium. Electronic address: guy.vingerhoets@ugent.be.
  • Deblaere K; Ghent University Hospital, Department of Neuroradiology, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Electronic address: karel.deblaere@ugent.be.
Eur J Paediatr Neurol ; 23(3): 525-536, 2019 May.
Article en En | MEDLINE | ID: mdl-31023628
Traumatic brain injury (TBI) is a heterogeneous disorder in which diffuse axonal injury (DAI) is an important component contributing to executive dysfunction. During adolescence, developing brain networks are especially vulnerable to acceleration-deceleration forces. We aimed to examine the correlation between DAI (number and localization) and executive functioning in adolescents with TBI. We recruited 18 adolescents with a mean age of 15y8m (SD = 1y7m), averaging 2.5 years after sustaining a moderate-to-severe TBI with documented DAI. Susceptibility Weighted Imaging sequence was administered to localize the DAI lesions. The adolescents performed a neurocognitive test-battery, addressing different aspects of executive functioning (working memory, attention, processing speed, planning ability) and their parents completed the Behavior Rating Inventory of Executive Function (BRIEF) - questionnaire. Executive performance of the TBI-group was compared with an age and gender matched control group of typically developing peers. Based on these results we focused on the Stockings of Cambridge test and the BRIEF to correlate with the total number and location of DAI. Results revealed that the anatomical distribution of DAI, especially in the corpus callosum and the deep brain nuclei, may have more implications for executive functioning than the total amount of DAI in adolescents. Results of this study may help guide targeted rehabilitation to redirect the disturbed development of executive function in adolescents with TBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesión Axonal Difusa / Función Ejecutiva / Lesiones Traumáticas del Encéfalo Tipo de estudio: Qualitative_research Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Eur J Paediatr Neurol Asunto de la revista: NEUROLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesión Axonal Difusa / Función Ejecutiva / Lesiones Traumáticas del Encéfalo Tipo de estudio: Qualitative_research Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Eur J Paediatr Neurol Asunto de la revista: NEUROLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido