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Protection conferred by a vaccine derived from an inactivated Egyptian variant of infectious bronchitis virus: a challenge experiment.
Al-Ebshahy, Emad; Abdel-Sabour, Mohammed; Abas, Osama; Yanai, Tokuma.
Afiliación
  • Al-Ebshahy E; Department of Microbiology, Faculty of Veterinary Medicine, Alexandria University, Edfina, Alexandria, 22758, Egypt.
  • Abdel-Sabour M; Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, 11381, Egypt.
  • Abas O; Department of Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Edfina, Alexandria, 22758, Egypt. dr_osamaabas2020@yahoo.com.
  • Yanai T; Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Trop Anim Health Prod ; 51(7): 1997-2001, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31020540
The current study investigated the protective efficacy of a formalin-inactivated infectious bronchitis virus (IBV) vaccine derived from the field strain KP729422, which exhibits low S1 spike protein sequence homology (77.1-79.8%) with the currently used vaccine strains in Egypt. Two-week-old, specific-pathogen-free chickens were subcutaneously inoculated with a single dose of the vaccine containing 106.7 50% embryo infective dose (EID50) of the inactivated virus. At 6 weeks of age, the chickens were challenged with 104 EID50 of the same virus strain via the oculonasal route. In comparison with the unvaccinated challenged group, the vaccinated chickens had significantly higher IBV-neutralizing antibody titers and exhibited efficient protection against challenge on the basis of tracheal ciliary activity. However, the challenge virus was recovered from the kidneys and tracheas of these chickens at rates of 40% and 60%, respectively. These findings suggest that a single application of the vaccine may provide sufficient clinical and respiratory protection, but may not ensure complete protection against infection by the challenge virus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Vacunas Virales / Pollos / Infecciones por Coronavirus / Virus de la Bronquitis Infecciosa Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Trop Anim Health Prod Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Vacunas Virales / Pollos / Infecciones por Coronavirus / Virus de la Bronquitis Infecciosa Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Trop Anim Health Prod Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos