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Leucinostatin Y: A Peptaibiotic Produced by the Entomoparasitic Fungus Purpureocillium lilacinum 40-H-28.
Momose, Isao; Onodera, Takefumi; Doi, Hiroyasu; Adachi, Hayamitsu; Iijima, Masatomi; Yamazaki, Yohko; Sawa, Ryuichi; Kubota, Yumiko; Igarashi, Masayuki; Kawada, Manabu.
Afiliación
  • Momose I; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
  • Onodera T; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
  • Doi H; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
  • Adachi H; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
  • Iijima M; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
  • Yamazaki Y; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
  • Sawa R; Institute of Microbial Chemistry (BIKAKEN) , Tokyo, 3-14-23 Kamiosaki , Shinagawa-ku , Tokyo 141-0021 , Japan.
  • Kubota Y; Institute of Microbial Chemistry (BIKAKEN) , Tokyo, 3-14-23 Kamiosaki , Shinagawa-ku , Tokyo 141-0021 , Japan.
  • Igarashi M; Institute of Microbial Chemistry (BIKAKEN) , Tokyo, 3-14-23 Kamiosaki , Shinagawa-ku , Tokyo 141-0021 , Japan.
  • Kawada M; Institute of Microbial Chemistry (BIKAKEN) , Numazu, 18-24 Miyamoto , Numazu-shi , Shizuoka 410-0301 , Japan.
J Nat Prod ; 82(5): 1120-1127, 2019 05 24.
Article en En | MEDLINE | ID: mdl-31017786
Leucinostatin Y, a new peptaibiotic, was isolated from the culture broth of the entomoparasitic fungus Purpureocillium lilacinum 40-H-28. The planar structure was elucidated by detailed analysis of its NMR and MS/MS data. The absolute configurations of the amino acids were partially determined by an advanced Marfey's method. The biological activities of leucinostatin Y were assessed using human pancreatic cancer cells, revealing the importance of the C-terminus of leucinostatins for preferential cytotoxicity to cancer cells under glucose-deprived conditions and inhibition of mitochondrial function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paecilomyces / Peptaiboles / Antineoplásicos Límite: Humans Idioma: En Revista: J Nat Prod Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paecilomyces / Peptaiboles / Antineoplásicos Límite: Humans Idioma: En Revista: J Nat Prod Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos