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A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.
Nascimento, Camila; Nunes, Villela Paula; Diehl Rodriguez, Roberta; Takada, Leonel; Suemoto, Cláudia Kimie; Grinberg, Lea Tenenholz; Nitrini, Ricardo; Lafer, Beny.
Afiliación
  • Nascimento C; Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. Electronic address: camisnascimento@usp.br.
  • Nunes VP; Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. Electronic address: paula@formato.com.br.
  • Diehl Rodriguez R; Behavioral and Cognitive Neurology Unit, Department of Neurology and LIM 22, University of São Paulo, São Paulo 05403-900, Brazil.
  • Takada L; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo, São Paulo 05403-900, Brazil.
  • Suemoto CK; Division of Geriatrics, LIM-22, University of São Paulo Medical School, São Paulo 01246-90, Brazil.
  • Grinberg LT; Department of Pathology, LIM-22, University of São Paulo Medical School, São Paulo 01246-90, Brazil; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143-120, USA. Electronic address: Lea.Grinberg@ucsf.edu.
  • Nitrini R; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo, São Paulo 05403-900, Brazil.
  • Lafer B; Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Prog Neuropsychopharmacol Biol Psychiatry ; 93: 269-283, 2019 07 13.
Article en En | MEDLINE | ID: mdl-31014945
Mental disorders are highly prevalent and important causes of medical burden worldwide. Co-occurrence of neurological and psychiatric symptoms are observed among mental disorders, representing a challenge for their differential diagnosis. Psychiatrists and neurologists have faced challenges in diagnosing old adults presenting behavioral changes. This is the case for early frontotemporal dementia (FTD) and bipolar disorder. In its initial stages, FTD is characterized by behavioral or language disturbances in the absence of cognitive symptoms. Consequently, patients with the behavioral subtype of FTD (bv-FTD) can be initially misdiagnosed as having a psychiatric disorder, typically major depression disorder (MDD) or bipolar disorder (BD). Bipolar disorder is associated with a higher risk of dementia in older adults and with cognitive impairment, with a subset of patients presents a neuroprogressive pattern during the disease course. No mendelian mutations were identified in BD, whereas three major genetic causes of FTD have been identified. Clinical similarities between BD and bv-FTD raise the question whether common molecular pathways might explain shared clinical symptoms. Here, we reviewed existing data on clinical and molecular similarities between BD and FTD to propose biological pathways that can be further investigated as common or specific markers of BD and FTD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Demencia Frontotemporal Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Demencia Frontotemporal Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido