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An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer.
Chu, Dinh-Toi; Bac, Nguyen Duy; Nguyen, Khanh-Hoang; Tien, Nguyen Le Bao; Thanh, Vo Van; Nga, Vu Thi; Ngoc, Vo Truong Nhu; Anh Dao, Duong Thi; Hoan, Le Ngoc; Hung, Nguyen Phuc; Trung Thu, Nguyen Thi; Pham, Van-Huy; Vu, Le Nguyen; Pham, Thuy Anh Vu; Thimiri Govinda Raj, Deepak B.
Afiliación
  • Chu DT; Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam. chudinhtoi.hnue@gmail.com.
  • Bac ND; School of Odonto Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam. chudinhtoi.hnue@gmail.com.
  • Nguyen KH; Institute of Cancer Research, Oslo University Hospital, 0372 Oslo, Norway. chudinhtoi.hnue@gmail.com.
  • Tien NLB; Department of Education and Training, Vietnam Military Medical University, Hanoi 100000, Vietnam. bac_hvqy@yahoo.com.
  • Thanh VV; National Food Institute, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark. hoangtc@gmail.com.
  • Nga VT; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam. bstiencsvd@gmail.com.
  • Ngoc VTN; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam. thanhvo@hmu.edu.vn.
  • Anh Dao DT; Institute for Research and Development, Duy Tan University, 03 Quang Trung, Danang 550000, Vietnam. vunguyenphuong.n@gmail.com.
  • Hoan LN; School of Odonto Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam. votruongnhungoc@gmail.com.
  • Hung NP; Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam. daodangduc@gmail.com.
  • Trung Thu NT; Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam. lengochoan@gmail.com.
  • Pham VH; Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam. hungnp@hnue.edu.vn.
  • Vu LN; Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam. trungthuhnue@gmail.com.
  • Pham TAV; AI Lab, Faculty of Information Technology, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam. phamvanhuy@tdtu.edu.vn.
  • Thimiri Govinda Raj DB; Organ Transplantation Center, Viet Duc Hospital, Hanoi 100000, Vietnam. nguyenvu.urologue@gmail.com.
Int J Mol Sci ; 20(8)2019 Apr 12.
Article en En | MEDLINE | ID: mdl-31013788
The selective expression of CD137 on cells of the immune system (e.g., T and DC cells) and oncogenic cells in several types of cancer leads this molecule to be an attractive target to discover cancer immunotherapy. Therefore, specific antibodies against CD137 are being studied and developed aiming to activate and enhance anti-cancer immune responses as well as suppress oncogenic cells. Accumulating evidence suggests that anti-CD137 antibodies can be used separately to prevent tumor in some cases, while in other cases, these antibodies need to be co-administered with other antibodies or drugs/vaccines/regents for a better performance. Thus, in this work, we aim to update and discuss current knowledge about anti-cancer effects of anti-CD137 antibodies as mono- and combined-immunotherapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral / Terapia Molecular Dirigida / Antineoplásicos Inmunológicos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral / Terapia Molecular Dirigida / Antineoplásicos Inmunológicos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza