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IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials.
Chisholm, Karen M; Mohlman, Jeffrey; Liew, Michael; Termuhlen, Amanda; Cairo, Mitchell S; Gross, Thomas G; Perkins, Sherrie L; Miles, Rodney R.
Afiliación
  • Chisholm KM; Department of Laboratories, Seattle Children's Hospital, Seattle, Washington.
  • Mohlman J; Department of Laboratory Medicine, University of Washington, Seattle, Washington.
  • Liew M; Department of Pathology, University of Utah, Salt Lake City, Utah.
  • Termuhlen A; ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah.
  • Cairo MS; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.
  • Gross TG; Department of Pediatrics, Medicine, Pathology, Microbiology and Immunology and Cell Biology and Anatomy, New York Medical College, Valhalla, New York.
  • Perkins SL; National Cancer Institute, Bethesda, Maryland.
  • Miles RR; Department of Pathology, University of Utah, Salt Lake City, Utah.
Pediatr Blood Cancer ; 66(8): e27770, 2019 08.
Article en En | MEDLINE | ID: mdl-31012208
Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Reordenamiento Génico / Biomarcadores de Tumor / Linfoma Folicular / Linfoma de Células B Grandes Difuso / Factores Reguladores del Interferón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Reordenamiento Génico / Biomarcadores de Tumor / Linfoma Folicular / Linfoma de Células B Grandes Difuso / Factores Reguladores del Interferón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos