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Low dose 100 cGy irradiation as a potential therapy for pulmonary hypertension.
Egan, Pamela C; Liang, Olin D; Goldberg, Laura R; Aliotta, Jason M; Pereira, Mandy; Borgovan, Theodor; Dooner, Mark; Camussi, Giovanni; Klinger, James R; Quesenberry, Peter J.
Afiliación
  • Egan PC; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Liang OD; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Goldberg LR; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Aliotta JM; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Pereira M; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Borgovan T; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Dooner M; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Camussi G; Department of Medical Sciences, University of Torino, Torino, Italy.
  • Klinger JR; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Quesenberry PJ; Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
J Cell Physiol ; 234(11): 21193-21198, 2019 11.
Article en En | MEDLINE | ID: mdl-31012111
Pulmonary hypertension (PH) is an incurable disease characterized by pulmonary vascular remodeling and ultimately death. Two rodent models of PH include treatment with monocrotaline or exposure to a vascular endothelial growth factor receptor inhibitor and hypoxia. Studies in these models indicated that damaged lung cells evolve extracellular vesicles which induce production of progenitors that travel back to the lung and induce PH. A study in patients with pulmonary myelofibrosis and PH indicated that 100 cGy lung irradiation could remit both diseases. Previous studies indicated that murine progenitors were radiosensitive at very low doses, suggesting that 100 cGy treatment of mice with induced PH might be an effective PH therapy. Our hypothesis is that the elimination of the PH-inducing marrow cells by low dose irradiation would remove the cellular influences creating PH. Here we show that low dose whole-body irradiation can both prevent and reverse established PH in both rodent models of PH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Irradiación Corporal Total / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Irradiación Corporal Total / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos