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Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials.
Hieu, Truong Hong; Dibas, Mahmoud; Surya Dila, Kadek Agus; Sherif, Nourin Ali; Hashmi, Muhammad Usman; Mahmoud, Mostafa; Trang, Nguyen Thi Thuy; Abdullah, Lava; Nghia, Thai Le Ba; Y, Mai Nhu; Hirayama, Kenji; Huy, Nguyen Tien.
Afiliación
  • Hieu TH; Faculty of Medicine, University of Medicine of Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  • Dibas M; Online Research Club (http://www.onlineresearchclub.org), Nagasaki, Japan.
  • Surya Dila KA; Online Research Club (http://www.onlineresearchclub.org), Nagasaki, Japan.
  • Sherif NA; Sulaiman Al Rajhi Colleges, College of Medicine, Qassim, Saudi Arabia.
  • Hashmi MU; Online Research Club (http://www.onlineresearchclub.org), Nagasaki, Japan.
  • Mahmoud M; Kubutambahan II Public Health Center, Singaraja, 81172, Indonesia.
  • Trang NTT; Online Research Club (http://www.onlineresearchclub.org), Nagasaki, Japan.
  • Abdullah L; Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Nghia TLB; Online Research Club (http://www.onlineresearchclub.org), Nagasaki, Japan.
  • Y MN; Department of General Medicine, Nishtar Medical University, Multan, Punjab, Pakistan.
  • Hirayama K; Online Research Club (http://www.onlineresearchclub.org), Nagasaki, Japan.
  • Huy NT; Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Phytother Res ; 33(6): 1604-1615, 2019 Jun.
Article en En | MEDLINE | ID: mdl-31006899
This systematic review and meta-analysis aimed to study the efficacy and safety of chamomile for the treatment of state anxiety, generalized anxiety disorders (GADs), sleep quality, and insomnia in human. Eleven databases including PubMed, Science Direct, Cochrane Central, and Scopus were searched to retrieve relevant randomized control trials (RCTs), and 12 RCTs were included. Random effect meta-analysis was performed by meta package of R statistical software version 3.4.3 and RevMan version 5.3. Our meta-analysis of three RCTs did not show any difference in case of anxiety (standardized mean difference = -0.15, 95% CI [-0.46, 0.16], P = 0.4214). Moreover, there is only one RCT that evaluated the effect of chamomile on insomnia and it found no significant change in insomnia severity index (P > 0.05). By using HAM-A scale, there was a significant improvement in GAD after 2 and 4 weeks of treatment (mean difference = -1.43, 95% CI [-2.47, -0.39], P = 0.007), (MD = -1.79, 95% CI [-3.14, -0.43], P = 0.0097), respectively. Noteworthy, our meta-analysis showed a significant improvement in sleep quality after chamomile administration (standardized mean difference = -0.73, 95% CI [-1.23, -0.23], P < 0.005). Mild adverse events were only reported by three RCTs. Chamomile appears to be efficacious and safe for sleep quality and GAD. Little evidence is there to show its effect on anxiety and insomnia. Larger RCTs are needed to ascertain these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Trastornos de Ansiedad / Sueño / Extractos Vegetales / Manzanilla / Trastornos del Inicio y del Mantenimiento del Sueño Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Trastornos de Ansiedad / Sueño / Extractos Vegetales / Manzanilla / Trastornos del Inicio y del Mantenimiento del Sueño Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Reino Unido