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Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats.
Lee, Li-Ya; Li, I-Chen; Chen, Wan-Ping; Tsai, Yueh-Ting; Chen, Chin-Chu; Tung, Kwong-Chung.
Afiliación
  • Lee LY; College of Veterinary Medicine, National Chung Hsing University, Taichung City, Taiwan.
  • Li IC; Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan.
  • Chen WP; Testing Center, Super Laboratory Inc., New Taipei City, Taiwan.
  • Tsai YT; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan.
  • Chen CC; Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan; Institute of Biotechnology, National Changhua University of Education, Changhua County, Taiwan.
  • Tung KC; College of Veterinary Medicine, National Chung Hsing University, Taichung City, Taiwan.
Int J Med Mushrooms ; 21(4): 401-411, 2019.
Article en En | MEDLINE | ID: mdl-31002635
Recently, erinacine A-enriched Hericium erinaceus (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease. Despite promising results from animal models, there have been no reports on its toxicity after long-term consumption. Hence, the present study was designed to evaluate the safety of EAHE mycelia through a 13-week subchronic rodent feeding study. Following 13 weeks of EAHE mycelia feeding at dosages of 0, 875, 1750, and 2625 mg/kg body weight in both male and female Sprague-Dawley rats, findings revealed neither any mortalities nor noticeable toxicological effects in all the rats during the investigation period. Physiological parameters including body weight and feed consumption patterns were unaffected by EAHE mycelia administration. The hematological and biochemical parameters as well as histopathological studies revealed no significant differences between the treatment and control groups. Conclusively, the obtained results suggested that EAHE mycelia could be relatively unharmful when used over an extended period, supporting its safe use in food preparation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Basidiomycota / Enfermedades Neurodegenerativas / Diterpenos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Med Mushrooms Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Basidiomycota / Enfermedades Neurodegenerativas / Diterpenos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Med Mushrooms Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos