Your browser doesn't support javascript.
loading
Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila.
Kachaev, Zaur M; Lebedeva, Lyubov A; Shaposhnikov, Alexander V; Moresco, James J; Yates, John R; Schedl, Paul; Shidlovskii, Yulii V.
Afiliación
  • Kachaev ZM; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Lebedeva LA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Shaposhnikov AV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Moresco JJ; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Yates JR; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Schedl P; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Shidlovskii YV; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
FEBS Lett ; 593(10): 1102-1112, 2019 05.
Article en En | MEDLINE | ID: mdl-31001806
The Paip2 protein is a factor regulating mRNA translation and stability in the cytoplasm. It has also been found in the nuclei of several cell types in Drosophila. Here, we aim to elucidate the functions of Paip2 in the cell nucleus. We find that nuclear Paip2 is a component of an ~300-kDa protein complex. Paip2 interacts with mRNA capping factor and factors of RNA polymerase II (Pol II) transcription initiation and early elongation. Paip2 functionally cooperates with the Cbp80 subunit of the cap-binding complex, with both proteins ensuring proper Pol II C-terminal domain (CTD) Ser5 phosphorylation at the promoter. Thus, Paip2 is a novel player at the stage of mRNA capping and early Pol II elongation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Polimerasa II / Regiones Promotoras Genéticas / Proteínas de Drosophila / Proteínas de Unión a Poli(A) / Complejo Proteico Nuclear de Unión a la Caperuza / Drosophila melanogaster Límite: Animals Idioma: En Revista: FEBS Lett Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Polimerasa II / Regiones Promotoras Genéticas / Proteínas de Drosophila / Proteínas de Unión a Poli(A) / Complejo Proteico Nuclear de Unión a la Caperuza / Drosophila melanogaster Límite: Animals Idioma: En Revista: FEBS Lett Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido