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Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways.
Qi, Guoyuan; Mi, Yashi; Fan, Rong; Li, Runnan; Liu, Zhigang; Liu, Xuebo.
Afiliación
  • Qi G; Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Mi Y; Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Fan R; Department of Nutrition and Health Sciences , University of Nebraska-Lincoln , Lincoln , Nebraska 68583 , United States.
  • Li R; Department of Animal and Food Science , University of Kentucky , Lexington , Kentucky 40506 , United States.
  • Liu Z; Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
  • Liu X; Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China.
J Agric Food Chem ; 67(18): 5122-5134, 2019 May 08.
Article en En | MEDLINE | ID: mdl-30995031
Neuroinflammation has been intensively demonstrated to be related to various neurodegenerative diseases including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD). A natural polymethoxylated flavone, nobiletin (NOB) has been reported to alleviate oxidative stress, insulin resistance, and obesity. In this study, we evaluated the protection effects of NOB on neuroinflammation and memory deficit. Three-month mice were administrated with NOB by oral gavage every day for 6 weeks (100 mg/kg/day); subsequently mice were injected intraperitoneally with lipopolysaccharide (LPS) for 7 days. Results of behavioral tests revealed that NOB dramatically ameliorated LPS-triggered memory deficit regarding synaptic dysfunctions and neuronal loss. Also, NOB suppressed the microglial activation and proinflammatory cytokine secretion, such as COX-2, IL-1ß, TNF-α, and iNOS. Similarly, upon LPS stimulation, pretreatment NOB diminished the secretion of the proinflammatory cytokines in BV-2 microglia cells by exposure to LPS via modulating MAPKs, PI3K/AKT, and NF-κB signaling pathways. In addition, NOB alleviated LPS-amplified redox imbalance, disturbance of mitochondrial membrane potential (MMP), and dampening of the expression of protein related to mitochondrial respiration. The present study provides compelling evidence that NOB decreased LPS-stimulated neuroinflammation and memory impairment through maintaining cellular oxidative balance and blocking the NF-κB transcriptional pathway, illustrating that the nutritional compound NOB may serve as a potential approach to alleviate neuroinflammation-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Quinasas de Proteína Quinasa Activadas por Mitógenos / Flavonas / Inflamación / Trastornos de la Memoria Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Quinasas de Proteína Quinasa Activadas por Mitógenos / Flavonas / Inflamación / Trastornos de la Memoria Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos