Influences of cytochrome b5 expression and its genetic variant on the activity of CYP2C9, CYP2C19 and CYP3A4.

Yoo, Sung-Eun; Yi, MyeongJin; Kim, Woo-Young; Cho, Sun-Ah; Lee, Sang Seop; Lee, Su-Jun; Shin, Jae-Gook

Yoo, Sung-Eun; Yi, MyeongJin; Kim, Woo-Young; Cho, Sun-Ah; Lee, Sang Seop; Lee, Su-Jun; Shin, Jae-Gook.

Afiliación

Yoo SE; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Yi M; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Kim WY; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Cho SA; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Lee SS; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Lee SJ; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea. Electronic address: 2sujun@inje.ac.kr.
Shin JG; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea. Electronic address: phshinjg@gmail.com.

Drug Metab Pharmacokinet ; 34(3): 201-208, 2019 Jun.

Article en En | MEDLINE | ID: mdl-30992242

Asunto(s)

Citocromo P-450 CYP2C19/metabolismo; Citocromo P-450 CYP2C9/metabolismo; Citocromo P-450 CYP3A/metabolismo; Citocromos b5/genética; Variación Genética; Hígado/metabolismo; Empalme Alternativo; Citocromo P-450 CYP2C19/genética; Citocromo P-450 CYP2C9/genética; Citocromo P-450 CYP3A/genética; Citocromos b5/metabolismo; Humanos; Técnicas In Vitro; Hígado/enzimología; Midazolam/metabolismo; Omeprazol/metabolismo; Tolbutamida/metabolismo

Palabras clave

CYP2C19; CYP2C9; CYP3A4; Cytochrome b5; Genetic polymorphism; Human liver microsome; Metabolism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Citocromos b5 / Citocromo P-450 CYP3A / Citocromo P-450 CYP2C9 / Citocromo P-450 CYP2C19 / Hígado Límite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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