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Network based statistics reveals trophic and neuroprotective effect of early high dose erythropoetin on brain connectivity in very preterm infants.
Jakab, A; Ruegger, C; Bucher, H U; Makki, Malek; Huppi, P S; Tuura, R; Hagmann, C.
Afiliación
  • Jakab A; Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland. Electronic address: Andras.Jakab@kispi.uzh.ch.
  • Ruegger C; Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
  • Bucher HU; Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
  • Makki M; Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland.
  • Huppi PS; Division of Development and Growth, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.
  • Tuura R; Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland.
  • Hagmann C; Department of Neonatology, University Hospital Zurich, Zurich, Switzerland; Department of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland.
Neuroimage Clin ; 22: 101806, 2019.
Article en En | MEDLINE | ID: mdl-30991614
Periventricular white matter injury is common in very preterm infants and it is associated with long term neurodevelopmental impairments. While evidence supports the protective effects of erythropoetin (EPO) in preventing injury, we currently lack the complete understanding of how EPO affects the emergence and maturation of anatomical brain connectivity and function. In this case-control study, connectomic analysis based on diffusion MRI tractography was applied to evaluate the effect of early high-dose EPO in preterm infants. A whole brain, network-level analysis revealed a sub-network of anatomical brain connections in which connectivity strengths were significantly stronger in the EPO group. This distributed network comprised connections predominantly in the frontal and temporal lobe bilaterally, and the effect of EPO was focused on peripheral and feeder connections of the core structural connectivity network. EPO resulted in a globally increased clustering coefficient, higher global and average local efficiency, while higher strength and increased clustering was found for regions in the frontal lobe and cingulate gyrus. The connectivity network most affected by the EPO treatment showed a steeper increase graph theoretical measures with age compared to the placebo group. Our results demonstrate a weak but widespread effect of EPO on the structural connectivity network and a possible trophic effect of EPO reflected by increasing network segregation, predominantly in local connections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Eritropoyetina / Fármacos Neuroprotectores / Imagen de Difusión Tensora / Recien Nacido Extremadamente Prematuro / Red Nerviosa Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: Neuroimage Clin Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Eritropoyetina / Fármacos Neuroprotectores / Imagen de Difusión Tensora / Recien Nacido Extremadamente Prematuro / Red Nerviosa Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: Neuroimage Clin Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos