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Cooling the skin for assessing small-fibre function.
Leone, Caterina; Dufour, André; Di Stefano, Giulia; Fasolino, Alessandra; Di Lionardo, Andrea; La Cesa, Silvia; Galosi, Eleonora; Valeriani, Massimiliano; Nolano, Maria; Cruccu, Giorgio; Truini, Andrea.
Afiliación
  • Leone C; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Dufour A; Centre d'Investigations Neurocognitives et Neurophysiologiques (CI2N), CNRS, University of Strasbourg, Strasbourg, France.
  • Di Stefano G; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Fasolino A; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Di Lionardo A; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • La Cesa S; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Galosi E; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Valeriani M; Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark.
  • Nolano M; Headache Center, Ospedale Bambino Gesù, IRCCS, Rome, Italy.
  • Cruccu G; "Salvatore Maugeri" Foundation, Institute of Telese Terme (BN), Telese Terme, Benevento, Italy.
  • Truini A; Department of Human Neuroscience, Sapienza University, Rome, Italy.
Pain ; 160(9): 1967-1975, 2019 09.
Article en En | MEDLINE | ID: mdl-30985621
In this clinical and neurophysiological study using a novel cold stimulator, we aim at investigating whether cold-evoked potentials (CEPs) may prove to be a reliable diagnostic tool to assess trigeminal small-fibre function. Using a novel device consisting of micro-Peltier elements, we recorded CEPs after stimulating the supraorbital and perioral regions and the hand dorsum in 15 healthy participants and in 2 patients with exemplary facial neuropathic pain conditions. We measured peripheral conduction velocity at the upper arm and studied the brain generators using source analysis. In healthy participants and patients, we also compared CEPs with laser-evoked potentials. In the healthy participants, cold stimulation evoked reproducible scalp potentials, similar to those elicited by laser pulses, although with a latency of about 30 ms longer. The mean peripheral conduction velocity, estimated at the upper arm, was 12.7 m/seconds. The main waves of the scalp potentials originated from the anterior cingulate gyrus and were preceded by activity in the bilateral opercular regions and bilateral dorsolateral frontal regions. Unlike laser stimulation, cold stimulation evoked scalp potential of similar amplitude across perioral, supraorbital, and hand dorsum stimulation. In patients with facial neuropathic pain, CEP recording showed the selective damage of cold pathways providing complementary information to laser-evoked potential recording. Our clinical and neurophysiological study shows that this new device provides reliable information on trigeminal small fibres mediating cold sensation and might be useful for investigating patients with facial neuropathic pain associated with a distinct damage of cold-mediating fibres.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Fenómenos Fisiológicos de la Piel / Frío / Neuropatía de Fibras Pequeñas / Hiperalgesia / Fibras Nerviosas Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Pain Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Fenómenos Fisiológicos de la Piel / Frío / Neuropatía de Fibras Pequeñas / Hiperalgesia / Fibras Nerviosas Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Pain Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos