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Novel Herpesvirus Associated With Oropharyngeal Squamous Cell Carcinoma in Smooth Green Snakes (Opheodrys vernalis).
Lovstad, Jessica N; Ossiboff, Robert J; Kinsel, Michael J; Gamble, Kathryn C.
Afiliación
  • Lovstad JN; 1 Lincoln Park Zoo, Chicago, IL, USA.
  • Ossiboff RJ; 2 Zoological Pathology Program, University of Illinois, Brookfield, IL, USA.
  • Kinsel MJ; 3 Aquatic, Amphibian, and Reptile Pathology Program, University of Florida, Gainesville, FL, USA.
  • Gamble KC; 2 Zoological Pathology Program, University of Illinois, Brookfield, IL, USA.
Vet Pathol ; 56(4): 630-635, 2019 07.
Article en En | MEDLINE | ID: mdl-30983531
During a 19-month period, 5 smooth green snakes (Opheodrys vernalis) maintained as an ex situ conservation colony presented with rapid clinical progression of locally invasive oropharyngeal squamous cell carcinoma. All 5 originated from the same wild source and were housed together or in close proximity. An infectious cause was considered likely, and nested conventional polymerase chain reaction (PCR) and in situ hybridization confirmed the presence of a novel alphaherpesvirus, Opheodrys herpesvirus 1, in the neoplastic tissue in 4 of the 5 snakes. Retrospective screening of previously submitted smooth green snakes by in situ hybridization did not detect virus in prior submissions from the colony. This report documents molecular characterization of an ophidian herpesvirus as well as colocalization of its viral nucleic acid with neoplastic transformation in snakes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Colubridae / Infecciones por Herpesviridae / Herpesviridae Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Vet Pathol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Colubridae / Infecciones por Herpesviridae / Herpesviridae Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Vet Pathol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos