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In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/ß-TCP Membranes for Guided Tissue Regeneration (GTR) Applications.
Chen, Chien-Chung; Lee, Sheng-Yang; Teng, Nai-Chia; Hu, Hsin-Tai; Huang, Pei-Chi; Yang, Jen-Chang.
Afiliación
  • Chen CC; Graduate Institute of Biomedical Materials & Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan. polyjack@tmu.edu.tw.
  • Lee SY; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. polyjack@tmu.edu.tw.
  • Teng NC; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan. seanlee@tmu.edu.tw.
  • Hu HT; Department of Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei 116, Taiwan. seanlee@tmu.edu.tw.
  • Huang PC; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan. tengnaichia@hotmail.com.
  • Yang JC; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan. hsintaihu1011@hotmail.com.
Nanomaterials (Basel) ; 9(4)2019 Apr 11.
Article en En | MEDLINE | ID: mdl-30979018
The guided tissue regeneration (GTR) membrane is a barrier intended to maintain a space for alveolar bone and periodontal ligament tissue regeneration but prevent the migration of fast-growing soft tissue into the defect sites. This study evaluated the physical properties, in vivo animal study, and clinical efficacy of hydrophilic PLA95/ß-TCP GTR membranes prepared by electrospinning (ES). The morphology and cytotoxicity of ES PLA95/ß-TCP membranes were evaluated by SEM and 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) respectively. The cementum and bone height were measured by an animal study at 8 and 16 weeks after surgery. Fifteen periodontal patients were selected for the clinical trial by using a commercial product and the ES PLA95/ß-TCP membrane. Radiographs and various indexes were measured six months before and after surgery. The average fiber diameter for this ES PLA95/ß-TCP membrane was 2.37 ± 0.86 µm. The MTT result for the ES PLA95/ß-TCP membrane showed negative for cytotoxicity. The significant differences in the cementum and bone height were observed between empty control and the ES PLA95/ß-TCP membrane in the animal model (p < 0.05). Clinical trial results showed clinical attachment level (CAL) of both control and ES PLA95/ß-TCP groups, with a significant difference from the pre-surgery results after six months. This study demonstrated that the ES PLA95/ß-TCP membrane can be used as an alternative GTR membrane for clinical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Nanomaterials (Basel) Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Nanomaterials (Basel) Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza