MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR.

You, Yu-Hui; Qin, Zhi-Qiang; Zhang, Huan-Li; Yuan, Zhao-Hong; Yu, Xin

You, Yu-Hui; Qin, Zhi-Qiang; Zhang, Huan-Li; Yuan, Zhao-Hong; Yu, Xin.

Afiliación

You YH; Department of Paediatric Rehabilitation, Affiliated Hospital of Jining Medical University, Jining 272029, P.R. China.
Qin ZQ; Department of Paediatric Rehabilitation, Affiliated Hospital of Jining Medical University, Jining 272029, P.R. China.
Zhang HL; Department of Paediatric Rehabilitation, Affiliated Hospital of Jining Medical University, Jining 272029, P.R. China.
Yuan ZH; Department of Paediatric Rehabilitation, Affiliated Hospital of Jining Medical University, Jining 272029, P.R. China.
Yu X; Department of Paediatric Rehabilitation, Affiliated Hospital of Jining Medical University, Jining 272029, P.R. China yuxin_jn@163.com.

Biosci Rep ; 39(6)2019 06 28.

Article en En | MEDLINE | ID: mdl-30975733

Asunto(s)

Trastorno Autístico/genética; Factor Neurotrófico Derivado del Encéfalo/genética; MicroARNs/genética; Receptores de Leptina/genética; Animales; Apoptosis/genética; Trastorno Autístico/patología; Ciclo Celular/genética; Proliferación Celular/genética; Modelos Animales de Enfermedad; Femenino; Regulación de la Expresión Génica/genética; Hipocampo/metabolismo; Hipocampo/patología; Humanos; Quinasas Janus/genética; Ratones; Neuronas/metabolismo; ARN Interferente Pequeño/genética; Factores de Transcripción STAT

Palabras clave

Autism; Brain-derived neurotrophic factor; Hippocampal neurons; JAK-STAT signaling pathway; Proliferation; microRNA-153

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Factor Neurotrófico Derivado del Encéfalo / MicroARNs / Receptores de Leptina Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Biosci Rep Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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