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Design, synthesis and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2.
Shah, Chetan P; Purushothaman, Gayathri; Thiruvenkatam, Vijay; Kirubakaran, Sivapriya; Juvale, Kapil; Kharkar, Prashant S.
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  • Shah CP; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS (Deemed to be University), V. L. Mehta Road, Vile Parle (West), Mumbai 400 056, India.
  • Purushothaman G; Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India.
  • Thiruvenkatam V; Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India; Physics, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India.
  • Kirubakaran S; Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India; Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India.
  • Juvale K; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS (Deemed to be University), V. L. Mehta Road, Vile Parle (West), Mumbai 400 056, India.
  • Kharkar PS; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS (Deemed to be University), V. L. Mehta Road, Vile Parle (West), Mumbai 400 056, India. Electronic address: Prashant.Kharkar@nmims.edu.
Bioorg Chem ; 87: 753-764, 2019 06.
Article en En | MEDLINE | ID: mdl-30974298
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofuranos / Helicobacter pylori / Inhibidores Enzimáticos / IMP Deshidrogenasa / Antibacterianos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofuranos / Helicobacter pylori / Inhibidores Enzimáticos / IMP Deshidrogenasa / Antibacterianos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos