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Early Measles Vaccination During an Outbreak in the Netherlands: Short-Term and Long-Term Decreases in Antibody Responses Among Children Vaccinated Before 12 Months of Age.
Brinkman, Iris D; de Wit, Jelle; Smits, Gaby P; Ten Hulscher, Hinke I; Jongerius, Maria C; Abreu, Taymara C; van der Klis, Fiona R M; Hahné, Susan J M; Koopmans, Marion P G; Rots, Nynke Y; van Baarle, Debbie; van Binnendijk, Robert S.
Afiliación
  • Brinkman ID; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • de Wit J; Department of Viroscience, Erasmus Medical Center, Rotterdam.
  • Smits GP; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • Ten Hulscher HI; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • Jongerius MC; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • Abreu TC; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • van der Klis FRM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • Hahné SJM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • Koopmans MPG; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • Rots NY; Department of Viroscience, Erasmus Medical Center, Rotterdam.
  • van Baarle D; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
  • van Binnendijk RS; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.
J Infect Dis ; 220(4): 594-602, 2019 07 19.
Article en En | MEDLINE | ID: mdl-30972418
BACKGROUND: The majority of infants will not be protected by maternal antibodies until their first measles vaccination, between 12 and 15 months of age. This provides incentive to reduce the age at measles vaccination, but immunological consequences are insufficiently understood, and long-term effects are largely unknown. METHODS: A total of 79 infants who received early measles vaccination between 6 and 12 months age and a second dose at 14 months of age were compared to 44 children in a control group who received 1 dose at 14 months of age. Measles virus-specific neutralizing antibody concentrations and avidity were determined up to 4 years of age. RESULTS: Infants who first received measles vaccination before 12 months of age had a long-term decrease in the concentration and avidity of measles virus-specific neutralizing antibodies, compared with infants in the control group. For 11.1% of children with a first dose before 9 months of age, antibody levels at 4 years of age had dropped below the cutoff for clinical protection. CONCLUSIONS: Early measles vaccination provides immediate protection in the majority of infants but yields a long-term decrease in neutralizing antibody responses, compared to vaccination at a later age. Additional vaccination at 14 months of age does not improve this. Over the long term, this may result in an increasing number of children susceptible to measles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacuna Antisarampión / Brotes de Enfermedades / Vacunación / Anticuerpos Neutralizantes / Sarampión / Virus del Sarampión / Anticuerpos Antivirales Límite: Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: J Infect Dis Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacuna Antisarampión / Brotes de Enfermedades / Vacunación / Anticuerpos Neutralizantes / Sarampión / Virus del Sarampión / Anticuerpos Antivirales Límite: Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: J Infect Dis Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos