Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.

Irani, Seema; Sipe, Sarah N; Yang, Wanjie; Burkholder, Nathaniel T; Lin, Brian; Sim, Kelly; Matthews, Wendy L; Brodbelt, Jennifer S; Zhang, Yan

Irani, Seema; Sipe, Sarah N; Yang, Wanjie; Burkholder, Nathaniel T; Lin, Brian; Sim, Kelly; Matthews, Wendy L; Brodbelt, Jennifer S; Zhang, Yan.

Afiliación

Irani S; Department of Chemical Engineering, The University of Texas, Austin, Texas 78712; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Sipe SN; Department of Chemistry, The University of Texas, Austin, Texas 78712.
Yang W; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Burkholder NT; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Lin B; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Sim K; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Matthews WL; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Brodbelt JS; Department of Chemistry, The University of Texas, Austin, Texas 78712.
Zhang Y; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712; Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712. Electronic address: jzhang@cm.utexas.edu.

J Biol Chem ; 294(21): 8592-8605, 2019 05 24.

Article en En | MEDLINE | ID: mdl-30971428

Asunto(s)

Proteínas de Drosophila/química; Proteínas Tirosina Fosfatasas/química; ARN Polimerasa II/química; Secuencias de Aminoácidos; Animales; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Drosophila melanogaster; Fosforilación; Proteínas Tirosina Fosfatasas/genética; Proteínas Tirosina Fosfatasas/metabolismo; ARN Polimerasa II/genética; ARN Polimerasa II/metabolismo

Palabras clave

CTD code; DNA transcription; RNA polymerase II; X-ray crystallography; intrinsically disordered protein; mass spectrometry (MS); phosphatase; phosphoryl motif; proline isomerization; tyrosine phosphorylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Polimerasa II / Proteínas Tirosina Fosfatasas / Proteínas de Drosophila Límite: Animals Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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