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Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex.
Park, Taegyun; Kim, Ji Yup; Cho, Hyeoncheol; Moon, Hee Chul; Kim, Beom Jin; Park, Ji Hun; Hong, Daewha; Park, Joonhong; Choi, Insung S.
Afiliación
  • Park T; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. xorbs7467@kaist.ac.kr.
  • Kim JY; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. y123812@kaist.ac.kr.
  • Cho H; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. harry0305@kaist.ac.kr.
  • Moon HC; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. arbalest@kaist.ac.kr.
  • Kim BJ; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. kimbj20@kaist.ac.kr.
  • Park JH; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. pjh1987@kaist.ac.kr.
  • Hong D; Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Busan 46241, Korea. dwhong17@pusan.ac.kr.
  • Park J; Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, St. Mary's Hospital, Daejeon 34943, Korea. miziro@catholic.ac.kr.
  • Choi IS; Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. ischoi@kaist.ac.kr.
Polymers (Basel) ; 9(4)2017 Apr 13.
Article en En | MEDLINE | ID: mdl-30970819
The blood-type-mismatch problem, in addition to shortage of blood donation, in blood transfusion has prompted the researchers to develop universal blood that does not require blood typing. In this work, the "cell-in-shell" (i.e., artificial spore) approach is utilized to shield the immune-provoking epitopes on the surface of red blood cells (RBCs). Individual RBCs are successfully coated with supramolecular metal-organic coordination complex of ferric ion (FeIII) and tannic acid (TA). The use of isotonic saline (0.85% NaCl) is found to be critical in the formation of stable, reasonably thick (20 nm) shells on RBCs without any aggregation and hemolysis. The formed "RBC-in-shell" structures maintain their original shapes, and effectively attenuate the antibody-mediated agglutination. Moreover, the oxygen-carrying capability of RBCs is not deteriorated after shell formation. This work suggests a simple but fast method for generating immune-camouflaged RBCs, which would contribute to the development of universal blood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2017 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2017 Tipo del documento: Article Pais de publicación: Suiza