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Thalamocortical dysrhythmia in intraoperative recordings of focal epilepsy.
Martire, Daniel J; Wong, Simeon; Mikhail, Mirriam; Ochi, Ayako; Otsubo, Hiroshi; Snead, O Carter; Donner, Elizabeth; Ibrahim, George M.
Afiliación
  • Martire DJ; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute , Toronto, Ontario , Canada.
  • Wong S; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute , Toronto, Ontario , Canada.
  • Mikhail M; Institute of Biomaterials and Biomedical Engineering, University of Toronto , Toronto, Ontario , Canada.
  • Ochi A; Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.
  • Otsubo H; Division of Neurology, Hospital for Sick Children , Toronto, Ontario , Canada.
  • Snead OC; Division of Neurology, Hospital for Sick Children , Toronto, Ontario , Canada.
  • Donner E; Division of Neurology, Hospital for Sick Children , Toronto, Ontario , Canada.
  • Ibrahim GM; Division of Neurology, Hospital for Sick Children , Toronto, Ontario , Canada.
J Neurophysiol ; 121(6): 2020-2027, 2019 06 01.
Article en En | MEDLINE | ID: mdl-30969798
Resonant interactions between the thalamus and cortex subserve a critical role for maintenance of consciousness as well as cognitive functions. In states of abnormal thalamic inhibition, thalamocortical dysrhythmia (TCD) has been described. The characteristics of TCD include a slowing of resting oscillations, ectopic high-frequency activity, and increased cross-frequency coupling. Here, we demonstrate the presence of TCD in four patients who underwent resective epilepsy surgery with chronically implanted electrodes under anesthesia, continuously recording activity from brain regions at the periphery of the epileptogenic zone before and after resection. Following resection, we report an acceleration of the large-scale network resting frequency coincident with decreases in cross-frequency phase-amplitude coupling. Interregional functional connectivity in the surrounding cortex was also increased following resection of the epileptogenic focus. These findings provide evidence for the presence of TCD in focal epilepsy and highlight the importance of reciprocal thalamocortical oscillatory interactions in defining novel biomarkers for resective surgeries. NEW & NOTEWORTHY Thalamocortical dysrhythmia (TCD) occurs in the context of thalamic dysfacilitation and is characterized by slowing of resting oscillations, ectopic high-frequency activity, and cross-frequency coupling. We provide evidence for TCD in focal epilepsy by studying electrophysiological changes occurring at the periphery of the resection margin. We report acceleration of resting activity coincident with decreased cross-frequency coupling and increased functional connectivity. The study of TCD in epilepsy has implications as a biomarker and therapeutic target.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Corteza Cerebral / Epilepsias Parciales / Ondas Encefálicas / Conectoma / Electrocorticografía / Red Nerviosa Límite: Adult / Humans Idioma: En Revista: J Neurophysiol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Corteza Cerebral / Epilepsias Parciales / Ondas Encefálicas / Conectoma / Electrocorticografía / Red Nerviosa Límite: Adult / Humans Idioma: En Revista: J Neurophysiol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos