Studies on pristinamycin synergism in Staphylococcus aureus.
J Antibiot (Tokyo)
; 39(9): 1314-21, 1986 Sep.
Article
en En
| MEDLINE
| ID: mdl-3096929
Binding experiments were performed with both components of the pristinamycin complex (pristinamycin IA (PIA) and pristinamycin IIA (PIIA] using ribosomes from sensitive and resistant Staphylococcus aureus. Fluorescence polarization was used to measure PIA binding. The results obtained show a direct correlation between inhibition, synergy and the enhancement of the affinity of PIA for its receptor in the presence of PIIA. The uptake of PIA by intact cells seems to be directly correlated with affinity between PIA and ribosomes, a phenomenon which is probably shared with the macrolide antibiotics.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
/
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Reino Unido