Progestins and oral contraceptive-induced lipoprotein changes: a prospective study.
Contraception
; 34(2): 121-34, 1986 Aug.
Article
en En
| MEDLINE
| ID: mdl-3096633
ABSTRACT
PIP: In order to determine the effects on plasma lipoproteins of oral contraceptives containing progestins with varying androgenic potency, 136 healthy women were randomized into 3 groups and followed prospectively for 1 year while receiving either 50 mcg ethinyl estradiol and 1.0 mg ethynodiol diacetate (EED), 50 mcg ethinyl estradiol and 1.0 mg norethindrone acetate (ENA), or 50 mcg ethinyl estradiol and 0.5 mg d-1 norgestrel (ENG). Comparison was made to a self-selected group of 50 women using alternative means of contraception. Plasma cholesterol increased by 7-9% and triglycerides by 32-57% in all 3 groups. ENG use resulted in other significant lipoprotein changes including an 18% increase in low density lipoprotein cholesterol, a 13% fall in high density lipoprotein cholesterol and a 27% decline in high density lipoprotein-2 cholesterol. Apoprotein A-1 increased by 9% with ENA and by 11% with EED, but did not change significantly with ENG. Khis prospective study demonstrates that in oral contraceptive agents with identical estrogen, progestins with different androgenic potency produce major and different changes in plasms lipoproteins.
Palabras clave
Americas; Biology; Blood Proteins; Cholesterol; Comparative Studies; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Methods; Developed Countries; Developing Countries; Endocrine System; Ethinyl Estradiol; Ethynodiol Diacetate; Family Planning; Hematological Effects; Hemic System; Hormones; Lipids; Norethindrone; Norethindrone Acetate; Norgestrel; North America; Northern America; Oral Contraceptives; Oral Contraceptives, Combined; Physiology; Prospective Studies; Proteins; Research Methodology; Research Report; Serum Protein Effects; Studies; United States
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progestinas
/
Anticonceptivos Orales
/
Lipoproteínas
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos