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Ceftaroline as salvage therapy for complicated MRSA bacteremia: case series and analysis.
Bhowmick, Tanaya; Liu, Charles; Imp, Brandon; Sharma, Ranita; Boruchoff, Susan E.
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  • Bhowmick T; Division of Allergy, Immunology and Infectious Diseases, Department of Medicine, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 362, New Brunswick, NJ, 08901, USA. Bhowmita@rwjms.rutgers.edu.
  • Liu C; Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, 125 Patterson Street, New Brunswick, NJ, 08901, USA.
  • Imp B; Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, 125 Patterson Street, New Brunswick, NJ, 08901, USA.
  • Sharma R; Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, 125 Patterson Street, New Brunswick, NJ, 08901, USA.
  • Boruchoff SE; Division of Allergy, Immunology and Infectious Diseases, Department of Medicine, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 362, New Brunswick, NJ, 08901, USA.
Infection ; 47(4): 629-635, 2019 Aug.
Article en En | MEDLINE | ID: mdl-30955166
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) is a major cause of morbidity and mortality in hospitalized patients. Ceftaroline fosamil (CPT) is the only available beta-lactam antibiotic with in vitro and in vivo activities against MRSA. There is currently limited clinical experience with CPT in complicated MRSA BSI. MATERIALS AND METHODS: We report a series of eight patients, including three whose strains had reduced susceptibility to vancomycin. RESULTS: CPT monotherapy was successfully used as salvage therapy for complicated MRSA BSI. The median time to documented clearance was 7 days. CONCLUSION: Ceftaroline monotherapy is effective for clearance of refractory MRSA BSI related to implanted devices, endocarditis, and orthopedic infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Cefalosporinas / Terapia Recuperativa / Bacteriemia / Staphylococcus aureus Resistente a Meticilina / Antibacterianos Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Infection Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Cefalosporinas / Terapia Recuperativa / Bacteriemia / Staphylococcus aureus Resistente a Meticilina / Antibacterianos Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Infection Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania