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Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.
Santos-Juanes, J; Fernández-Vega, I; Lorenzo-Herrero, S; Sordo-Bahamonde, C; Martínez-Camblor, P; García-Pedrero, J M; Vivanco, B; Galache-Osuna, C; Vazquez-Lopez, F; Gonzalez, S; Rodrigo, J P.
Afiliación
  • Santos-Juanes J; Service of Dermatology, Hospital Universitario Central de Asturias, Oviedo, Spain. jorgesantosjuanes@gmail.com.
  • Fernández-Vega I; Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain. jorgesantosjuanes@gmail.com.
  • Lorenzo-Herrero S; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain. jorgesantosjuanes@gmail.com.
  • Sordo-Bahamonde C; Service of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Martínez-Camblor P; Departamento de Cirugía y especialidades Médico-quirúrgicas, Universidad de Oviedo, Oviedo, Spain.
  • García-Pedrero JM; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.
  • Vivanco B; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain.
  • Galache-Osuna C; Department of Functional Biology, University of Oviedo, Oviedo, Spain.
  • Vazquez-Lopez F; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.
  • Gonzalez S; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain.
  • Rodrigo JP; Department of Functional Biology, University of Oviedo, Oviedo, Spain.
Arch Dermatol Res ; 311(5): 369-376, 2019 Jul.
Article en En | MEDLINE | ID: mdl-30955082
The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there are little data about LLT1 expression in human solid tumors. The objective of this paper is to investigate the relationship between LLT1 expression with the clinicopathologic features and its impact on the prognosis of head and neck cutaneous squamous cell carcinoma (cSCC). LLT1 expression was analyzed on paraffin-embedded tissue samples obtained from 100 patients with cSCC by immunohistochemistry. The estimator of Fine and Gray was used to estimate the cumulative incidence curves for relapse. Proportional Hazard models and Hazard ratios (HRs) were used for studying the risk of tumor relapse and mortality. LLT1 strong expression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 3.40 (95% CI 1.39-9.28) and 3.25 (95% CI 1.15-9.16); and for cSCC specific death of 6.17 (95% CI 1.79-21.2) and 6.10 (95% CI 1.45-25.7). Strong LLT1 expression is an independent predictor of nodal metastasis and poor disease-specific survival and it might be helpful for risk stratification of patients with cSCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Receptores de Superficie Celular / Lectinas Tipo C / Carcinoma de Células Escamosas de Cabeza y Cuello / Metástasis Linfática Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Arch Dermatol Res Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Receptores de Superficie Celular / Lectinas Tipo C / Carcinoma de Células Escamosas de Cabeza y Cuello / Metástasis Linfática Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Arch Dermatol Res Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania