Pueraria montana var. lobata root extract inhibits photoaging on skin through Nrf2 pathway.
J Microbiol Biotechnol
; 29(4): 518-526, 2019 Apr 28.
Article
en En
| MEDLINE
| ID: mdl-30954034
Pueraria montana var. lobata is a bioactive substance, in possession of a variety of beneficial health effects, which has long been extensively used as a traditional medication for the treatment of fever, acute dysentery, diabetes, and cardiovascular diseases in North-East Asian countries. The purpose of this study was to evaluate the cytoprotective activity of Pueraria montana var. lobata ethanol extract (PLE) for ultraviolet B (UVB) induced oxidative stress in human dermal fibroblasts (HDF). It was hypothesized that PLE treatment (25-100 µg/mL) would reduce intracellular reactive oxygen species (ROS) levels as well as increase collagen production in UVB-irradiated HDF. The results confirmed this theory, with collagen production increasing in the PLE treatment group in a dose-dependent manner. In addition, regulators of cellular ROS accumulation, including HO-1 and NOQ-1, were activated by Nrf2, which was mediated by PLE. Hence, intracellular levels of ROS were also reduced in the PLE treatment group in a dose-dependent manner. In conclusion, PLE increases collagen production and maintains hyaluronic acid (HA) levels in human dermal fibroblasts exposed to UVB-irradiation, thereby inhibiting photoaging.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
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Extractos Vegetales
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Envejecimiento de la Piel
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Raíces de Plantas
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Pueraria
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Factor 2 Relacionado con NF-E2
Idioma:
En
Revista:
J Microbiol Biotechnol
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Corea del Sur