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Medication-related osteonecrosis of the jaw in a minipig model: Parameters for developing a macroscopic, radiological, and microscopic grading scheme.
Nowicki, B; Nehrbass, D; Arens, D; Stadelmann, V A; Zeiter, S; Otto, S; Kircher, P; Stoddart, M J.
Afiliación
  • Nowicki B; AO Research Institute Davos, Davos Platz, Switzerland.
  • Nehrbass D; AO Research Institute Davos, Davos Platz, Switzerland.
  • Arens D; AO Research Institute Davos, Davos Platz, Switzerland.
  • Stadelmann VA; AO Research Institute Davos, Davos Platz, Switzerland.
  • Zeiter S; AO Research Institute Davos, Davos Platz, Switzerland.
  • Otto S; Department of Oral and Maxillofacial Surgery, University of Munich, Munich, Germany.
  • Kircher P; Department of Veterinary Radiology, University of Zurich, Zurich, Switzerland.
  • Stoddart MJ; AO Research Institute Davos, Davos Platz, Switzerland; Medical Faculty, Albert Ludwigs University of Freiburg, Freiburg, Germany. Electronic address: Martin.stoddart@aofoundation.org.
J Craniomaxillofac Surg ; 47(7): 1162-1169, 2019 Jul.
Article en En | MEDLINE | ID: mdl-30952472
OBJECTIVES: To devise a macroscopic, radiological, and histological scale for assessing pathological changes associated with medication-related osteonecrosis of the jaw in a minipig model. MATERIALS AND METHODS: Medication-related osteonecrosis of the jaw was induced in Göttingen minipigs by weekly intravenous administration of bisphosphonate (zoledronic acid) combined with a tooth extraction procedure. Controls either did not receive zoledronic acid or did not undergo tooth extraction. After 20 weeks, minipigs were euthanized and underwent computed tomography and micro-computed tomography scanning. The mandible underwent additional histological examination. RESULTS: The most consistent macroscopic findings in animals that had developed bisphosphonate-related osteonecrosis of the jaw (BRONJ) were necrotic, denuded bone, and formation of fistula and pus. Under radiological examination, impaired extraction socket healing, decrease in attenuation of bone beneath the extraction site, and periosteal reaction were observed. Under histological examination, demineralization of the extracellular bone matrix, denuding of bone, and osteonecrosis were recorded. CONCLUSION: These parameters were used to develop a scoring system for grading BRONJ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteonecrosis de los Maxilares Asociada a Difosfonatos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Craniomaxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteonecrosis de los Maxilares Asociada a Difosfonatos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Craniomaxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido