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Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.
Nishi, Yukiko; Murakami, Akikazu; Murayama, Yuko; Tsukahara, Narutoshi; Okamoto, Shiki; Nakachi, Sawako; Morichika, Kazuho; Tamaki, Keita; Noguchi, Hirofumi; Matsushita, Masayuki; Karube, Ken-Nosuke; Fukushima, Takuya; Morishima, Satoko; Kishimoto, Hidehiro; Masuzaki, Hiroaki.
Afiliación
  • Nishi Y; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Murakami A; Department of Parasitology & Immunopathoetiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Murayama Y; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Tsukahara N; Department of Parasitology & Immunopathoetiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Okamoto S; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Nakachi S; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Morichika K; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Tamaki K; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Noguchi H; Department of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Matsushita M; Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Karube KN; Department of Pathology and Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Fukushima T; Laboratory of Hematoimmunology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Morishima S; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Kishimoto H; Department of Parasitology & Immunopathoetiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Masuzaki H; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address: hiroaki@med.u-ryukyu.ac.jp.
Transpl Immunol ; 55: 101205, 2019 08.
Article en En | MEDLINE | ID: mdl-30946889
Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5.1) splenocytes without conditioning irradiation or chemotherapy. AD-MSCs from C3H mice were injected intravenously via tail veins. GVHD was assessed using flowcytometry analysis of peripheral blood cells and histopathologic analysis of target organs. Histopathological analyses revealed that AD-MSCs markedly suppressed the infiltration of lymphocytes into liver as well as the aplasia in bone marrow. This study is the first to clarify the effectiveness of AD-MSCs against bone marrow aplasia in GVHD, supporting a rationale of AD-MSCs for ameliorating bone marrow suppression and infectivity after allo-HSCT in human clinics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Médula Ósea / Trasplante de Células Madre Hematopoyéticas / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Transpl Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Médula Ósea / Trasplante de Células Madre Hematopoyéticas / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Transpl Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos