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The burden of vaccine-preventable diseases among HIV-infected and HIV-exposed children in sub-Saharan Africa: a systematic review and meta-analysis.
Adetokunboh, Olatunji O; Awotiwon, Ajibola; Ndwandwe, Duduzile; Uthman, Olalekan A; Wiysonge, Charles S.
Afiliación
  • Adetokunboh OO; Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
  • Awotiwon A; Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Cape Town, South Africa.
  • Ndwandwe D; Knowledge Translation Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
  • Uthman OA; Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
  • Wiysonge CS; Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
Hum Vaccin Immunother ; 15(11): 2590-2605, 2019.
Article en En | MEDLINE | ID: mdl-30945963
There are knowledge gaps regarding evidence-based research on the burden of vaccine-preventable diseases among human immunodeficiency virus (HIV)-infected and HIV-exposed children aged <18 years in sub-Saharan Africa. It is therefore essential to determine the trend and burden of vaccine-preventable diseases. We completed a systematic review and meta-analysis to identify the incidence, prevalence and case-fatality rates (CFR) attributed to various vaccine-preventable diseases among HIV-infected and HIV-exposed children in sub-Saharan Africa. The trends in the prevalence of vaccine-preventable diseases among HIV-infected and HIV-exposed children were also determined. Nine studies on tuberculosis (TB) were pooled to give an overall incidence rate estimate of 60 (95% confidence interval [CI] 30-70) per 1,000 child-years. The incidence of pneumococcal infections varied between 109-1509 per 100,000 while pertussis was between 2.9 and 3.7 per 1000 child-year. Twenty-two TB prevalence studies reported an estimated prevalence of 16%. Fifteen prevalence studies on hepatitis B infection were pooled together with an estimated prevalence of 5%. The pooled prevalence for pneumococcal infections was 2% while rotavirus diarrhoea reported a prevalence of 13%. Twenty-nine studies on TB were pooled to give an overall CFR estimate of 17% while pneumococcal infections in HIV-infected and exposed children were pooled together with a resultant rate of 15%. Some of the vaccine-preventable diseases still have high incidences, prevalence and CFR among HIV-infected and HIV-exposed children. There is also a dearth of research data on the burden of several vaccine-preventable diseases among HIV-infected and exposed children and a need for more studies in this area.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Costo de Enfermedad / Enfermedades Prevenibles por Vacunación Tipo de estudio: Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Child / Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Hum Vaccin Immunother Año: 2019 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Costo de Enfermedad / Enfermedades Prevenibles por Vacunación Tipo de estudio: Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Child / Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Hum Vaccin Immunother Año: 2019 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos