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(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.
Zanos, Panos; Highland, Jaclyn N; Liu, Xin; Troppoli, Timothy A; Georgiou, Polymnia; Lovett, Jacqueline; Morris, Patrick J; Stewart, Brent W; Thomas, Craig J; Thompson, Scott M; Moaddel, Ruin; Gould, Todd D.
Afiliación
  • Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Highland JN; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Liu X; Program in Toxicology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Troppoli TA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Georgiou P; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Lovett J; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Morris PJ; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
  • Stewart BW; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Thomas CJ; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Thompson SM; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Moaddel R; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Gould TD; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Br J Pharmacol ; 176(14): 2573-2592, 2019 07.
Article en En | MEDLINE | ID: mdl-30941749

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Depresión / Ketamina / Anestésicos / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Depresión / Ketamina / Anestésicos / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido