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[Restoration of tissue reparative ability during acute pancreatitis (in Russian only)]. / Vosstanovlenie reparativnoi sposobnosti tkanei pri ostrom pankreatite.
Vlasov, A P; Zaitsev, P P; Vlasova, T I; Okunev, N A; Sheyranov, N S; Bolotskikh, V A; Muratova, T A.
Afiliación
  • Vlasov AP; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
  • Zaitsev PP; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
  • Vlasova TI; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
  • Okunev NA; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
  • Sheyranov NS; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
  • Bolotskikh VA; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
  • Muratova TA; National Research Mordovia State University. N.P. Ogarev, Saransk, Russia.
Khirurgiia (Mosk) ; (3): 73-79, 2019.
Article en Ru | MEDLINE | ID: mdl-30938360
AIM: The purpose of the study was to establish the effectiveness of Remaxol in restoring tissue reparative ability of laparotomy wound in acute severe pancreatitis. MATERIAL AND METHODS: The work is based on the results of experimental and clinical studies. Experiments were carried out using acute total pancreatic necrosis model under anesthesia on 30 dogs. Furthermore, 28 patients with acute severe pancreatitis were examined and underwent surgery on various purulent-necrotic complications. In the postoperative period, healing and metabolic processes were evaluated in the tissues along the sutures line of the laparotomy wound. Also, such parameters as endogenous intoxication, oxidative stress, and phospholipase activity were evaluated at the organism level. In the studied groups, Remaxol is included in the postoperative therapy. RESULTS: It has been established that during acute severe pancreatitis reparative potential of tissues is significantly reduced, which is caused by a significant disruption of trophism, activation of phospholipases and peroxidation of membrane lipids. Disorders of homeokinesis at the organism level play a negative role in tissue reparative potential reduction. Inclusion of Remaxol in the complex therapy of acute pancreatitis leads to a decrease in duration of wound healing by reduction in the phase of inflammation. Optimization of the healing process occurs due to complex effect of the drug at organ and body level, which results in improvement of the trophism and, what's more, stabilizes membranes of regenerating cells. CONCLUSION: In case of acute severe pancreatitis, the use of Remaxol in early postoperative period in the complex therapy leads to a significant correction of factors that adversely affect regeneration and contributes to the restoration of tissue reparative potential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinatos / Cicatrización de Heridas / Pancreatitis Aguda Necrotizante / Herida Quirúrgica / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: Ru Revista: Khirurgiia (Mosk) Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinatos / Cicatrización de Heridas / Pancreatitis Aguda Necrotizante / Herida Quirúrgica / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: Ru Revista: Khirurgiia (Mosk) Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia