JNK signaling coordinates with ecdysone signaling to promote pruning of <i>Drosophila</i> sensory neuron dendrites.

Zhu, Sijun; Chen, Rui; Soba, Peter; Jan, Yuh-Nung

JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites.

Zhu, Sijun; Chen, Rui; Soba, Peter; Jan, Yuh-Nung.

Afiliación

Zhu S; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA zhus@upstate.edu.
Chen R; Department of Physiology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 20251, USA.
Soba P; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
Jan YN; Department of Physiology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 20251, USA.

Development ; 146(8)2019 04 17.

Article en En | MEDLINE | ID: mdl-30936183

RESUMEN

Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Interestingly, our data show that JNK activity in c4da neurons remains constant from larval to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved in dendrite pruning and a new downstream target of EcRB1 in c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite pruning.

Asunto(s)

Dendritas/metabolismo; Proteínas de Drosophila/metabolismo; Drosophila/citología; Drosophila/metabolismo; Ecdisona/metabolismo; Células Receptoras Sensoriales/citología; Células Receptoras Sensoriales/metabolismo; Animales; Proteínas de Drosophila/genética; Regulación del Desarrollo de la Expresión Génica/genética; Regulación del Desarrollo de la Expresión Génica/fisiología; Sistema de Señalización de MAP Quinasas/genética; Sistema de Señalización de MAP Quinasas/fisiología; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Transducción de Señal/genética; Transducción de Señal/fisiología

Palabras clave

Dendrite pruning; Drosophila; Ecdysone; JNK; Sensory neurons; Wnt5

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Receptoras Sensoriales / Proteínas de Drosophila / Dendritas / Drosophila / Ecdisona Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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