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Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice.
Mastinu, Andrea; Bonini, Sara Anna; Rungratanawanich, Wiramon; Aria, Francesca; Marziano, Mariagrazia; Maccarinelli, Giuseppina; Abate, Giulia; Premoli, Marika; Memo, Maurizio; Uberti, Daniela.
Afiliación
  • Mastinu A; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. andrea.mastinu@unibs.it.
  • Bonini SA; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. sara.bonini@unibs.it.
  • Rungratanawanich W; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. w.rungratanawani@unibs.it.
  • Aria F; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. f.aria@unibs.it.
  • Marziano M; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. m.marziano@unibs.it.
  • Maccarinelli G; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. giuseppina.maccarinelli@unibs.it.
  • Abate G; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. g.abate001@unibs.it.
  • Premoli M; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. m.premoli002@unibs.it.
  • Memo M; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. maurizio.memo@unibs.it.
  • Uberti D; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. daniela.uberti@unibs.it.
Nutrients ; 11(4)2019 Mar 29.
Article en En | MEDLINE | ID: mdl-30934852
BACKGROUND: Rice (Oryza sativa L.) is the main food source for more than half of humankind. Rice is rich in phytochemicals and antioxidants with several biological activities; among these compounds, the presence of γ-oryzanol is noteworthy. The present study aims to explore the effects of γ-oryzanol on cognitive performance in a mouse model of neuroinflammation and cognitive alterations. METHODS: Mice received 100 mg/kg γ-oryzanol (ORY) or vehicle once daily for 21 consecutive days and were then exposed to an inflammatory stimulus elicited by lipopolysaccharide (LPS). A novel object recognition test and mRNA expression of antioxidant and neuroinflammatory markers in the hippocampus were evaluated. RESULTS: ORY treatment was able to improve cognitive performance during the neuroinflammatory response. Furthermore, phase II antioxidant enzymes such as heme oxygenase-1 (HO-1) and NADPH-dehydrogenase-quinone-1 (NQO1) were upregulated in the hippocampi of ORY and ORY+LPS mice. Lastly, γ-oryzanol showed a strong anti-inflammatory action by downregulating inflammatory genes after LPS treatment. CONCLUSION: These results suggest that chronic consumption of γ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilpropionatos / Lipopolisacáridos / Encefalitis Límite: Animals Idioma: En Revista: Nutrients Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilpropionatos / Lipopolisacáridos / Encefalitis Límite: Animals Idioma: En Revista: Nutrients Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza