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Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models.
Ganesan, Palanivel; Kim, Byungwook; Ramalaingam, Prakash; Karthivashan, Govindarajan; Revuri, Vishnu; Park, Shinyoung; Kim, Joon Soo; Ko, Young Tag; Choi, Dong-Kug.
Afiliación
  • Ganesan P; Department of Integrated Bioscience-Biomedical Chemistry, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea. palanivel67@gmail.com.
  • Kim B; Nanotechnology Research Center and Department of Integrated Bioscience-Biotechnology, Konkuk University, Chungju 27478, Korea. palanivel67@gmail.com.
  • Ramalaingam P; Nanotechnology Research Center and Department of Integrated Bioscience-Biotechnology, Konkuk University, Chungju 27478, Korea. kbwxfile@gmail.com.
  • Karthivashan G; Department of Medical & Molecular Genetics, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. kbwxfile@gmail.com.
  • Revuri V; Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA 19104, USA. ramprabaprakash@gmail.com.
  • Park S; College of Pharmacy, Gachon University, Incheon 406-799, Korea. ramprabaprakash@gmail.com.
  • Kim JS; Nanotechnology Research Center and Department of Integrated Bioscience-Biotechnology, Konkuk University, Chungju 27478, Korea. karthivashan@gmail.com.
  • Ko YT; Department of Green Bio engineering Korea National University of Transportation, Daehakro 750, Chungju 27469, Korea. vishnurevuri91@gmail.com.
  • Choi DK; Nanotechnology Research Center and Department of Integrated Bioscience-Biotechnology, Konkuk University, Chungju 27478, Korea. ifresha@nate.com.
Molecules ; 24(6)2019 Mar 25.
Article en En | MEDLINE | ID: mdl-30934561
Curcumin, which is a potential antineuroinflammatory and neuroprotective compound, exhibits poor bioavailability in brain cells due to its difficulty in crossing the blood⁻brain barrier and its rapid metabolism during circulation, which decreases its efficacy in treating chronic neuroinflammatory diseases in the central nervous system. The bioavailability and potential of curcumin can be improved by using a nanodelivery system, which includes solid lipid nanoparticles. Curcumin-loaded solid lipid nanoparticles (SLCN) were efficiently developed to have a particle size of about 86 nm and do not exhibit any toxicity in the endothelial brain cells. Furthermore, the curcumin-loaded solid lipid nanoparticles (SLCN) were studied to assess their efficacy in BV-2 microglial cells against LPS-induced neuroinflammation. The SLCN showed a higher inhibition of nitric oxide (NO) production compared to conventional curcumin in a dose-dependent manner. Similarly, the mRNA and proinflammatory cytokine levels were also reduced in a dose-dependent manner when compared to those with free curcumin. Thus, SLCN could be a potential delivery system for curcumin to treat microglia-mediated neuroinflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Lipopolisacáridos / Microglía / Curcumina / Nanopartículas / Lípidos Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Lipopolisacáridos / Microglía / Curcumina / Nanopartículas / Lípidos Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Suiza