Your browser doesn't support javascript.
loading
MicroRNA-31 Regulates Immunosuppression in Ang II (Angiotensin II)-induced Hypertension by Targeting Ppp6C (Protein Phosphatase 6c).
Li, Xiangxiao; Cai, Wei; Xi, Wenda; Sun, Weihong; Shen, Weili; Wei, Tong; Chen, Xiaohui; Sun, Libo; Zhou, Hong; Sun, Yang; Chen, Wendong; Gao, Pingjin; Wang, Honglin; Li, Qun.
Afiliación
  • Li X; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Cai W; Department of Immunology and Microbiology, Shanghai Institute of Immunology (W.C., L.S., H.Z, Y.S., H.W.), Shanghai Jiao Tong University School of Medicine, China.
  • Xi W; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Sun W; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Shen W; Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, China (W.S.).
  • Wei T; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Chen X; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Sun L; Department of Immunology and Microbiology, Shanghai Institute of Immunology (W.C., L.S., H.Z, Y.S., H.W.), Shanghai Jiao Tong University School of Medicine, China.
  • Zhou H; Department of Immunology and Microbiology, Shanghai Institute of Immunology (W.C., L.S., H.Z, Y.S., H.W.), Shanghai Jiao Tong University School of Medicine, China.
  • Sun Y; Department of Immunology and Microbiology, Shanghai Institute of Immunology (W.C., L.S., H.Z, Y.S., H.W.), Shanghai Jiao Tong University School of Medicine, China.
  • Chen W; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Gao P; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
  • Wang H; Department of Immunology and Microbiology, Shanghai Institute of Immunology (W.C., L.S., H.Z, Y.S., H.W.), Shanghai Jiao Tong University School of Medicine, China.
  • Li Q; From the State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension (X.L., W.X., W.S., T.W., X.C., W.C., P.G., Q.L.), Shanghai Jiao Tong University School of Medicine, China.
Hypertension ; 73(5): e14-e24, 2019 05.
Article en En | MEDLINE | ID: mdl-30929511
Regulatory T cells (Treg cells) play important roles in hypertension and organ damages. MicroRNA-31 (miR-31) is a critical regulator for Treg cell generation. However, the role of miR-31 in hypertension has not been elucidated. We aim to study the functionality of miR-31 and the detailed mechanism in Ang II (Angiotensin II)-induced hypertensive mouse model. We found: In vitro, miR-31 expression was higher in T helper 17 cells and lower in Treg cells than that of naïve T cells. The genetic deficiency of miR-31 promoted Treg cell differentiation, whereas no impact on T helper 17 cells differentiation. Ang II-induced hypertension resulted in increased expression of miR-31 in the aorta, splenic CD4+ T cells, and kidney leukocytes. MiR-31 deficiency strikingly decreased systolic blood pressure and diastolic blood pressure and attenuated renal and vascular damage. MiR-31 deletion altered the accumulation of Treg cells and macrophages and expression of inflammatory cytokines in kidneys in Ang II-induced hypertensive mice. Ang II treatment reduced the levels of anti-inflammatory cytokines and increased proinflammatory cytokines in plasma that were blunted by the miR-31 deletion. Ppp6C (protein phosphatase 6c; a direct target of miR-31) specific deletion in Treg cells led to marked impairment of Treg cell induction, increased Ang II-induced blood pressure elevation, and organ damage in mice. In conclusion, we provided novel evidence of miR-31 as an emerging key posttranscriptional regulator of hypertension-associated immunosuppression through targeting ppp6C which is a critical regulator in the differentiation of Treg cells. This study offers new perspectives on miRNA-based therapeutic approaches.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Linfocitos T Reguladores / Fosfoproteínas Fosfatasas / MicroARNs / Hipertensión / Inmunidad Celular Límite: Animals Idioma: En Revista: Hypertension Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Linfocitos T Reguladores / Fosfoproteínas Fosfatasas / MicroARNs / Hipertensión / Inmunidad Celular Límite: Animals Idioma: En Revista: Hypertension Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos