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Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.
Lima-Fernandes, Evelyne; Murison, Alex; da Silva Medina, Tiago; Wang, Yadong; Ma, Anqi; Leung, Cherry; Luciani, Genna M; Haynes, Jennifer; Pollett, Aaron; Zeller, Constanze; Duan, Shili; Kreso, Antonija; Barsyte-Lovejoy, Dalia; Wouters, Bradly G; Jin, Jian; Carvalho, Daniel D De; Lupien, Mathieu; Arrowsmith, Cheryl H; O'Brien, Catherine A.
Afiliación
  • Lima-Fernandes E; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.
  • Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • da Silva Medina T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Wang Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Ma A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Leung C; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Luciani GM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Haynes J; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.
  • Pollett A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Zeller C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Duan S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S1A8, Canada.
  • Kreso A; Lunenfeld-Tanenbaum Research Institute Toronto, Toronto, ON, M5G1X5, Canada.
  • Barsyte-Lovejoy D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Wouters BG; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.
  • Jin J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Carvalho DD; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G1L7, Canada.
  • Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G1L7, Canada.
  • Arrowsmith CH; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7, Canada.
  • O'Brien CA; Department of Radiation Oncology, University of Toronto, Toronto, ON, M5G1L7, Canada.
Nat Commun ; 10(1): 1436, 2019 03 29.
Article en En | MEDLINE | ID: mdl-30926792
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales / Proteínas Hedgehog / Autorrenovación de las Células Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales / Proteínas Hedgehog / Autorrenovación de las Células Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido